Y350_HAEIN
ID Y350_HAEIN Reviewed; 425 AA.
AC P24326;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Uncharacterized protein HI_0350;
DE AltName: Full=ORF3;
GN OrderedLocusNames=HI_0350;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=RM 7004 / Serotype B;
RX PubMed=1956282; DOI=10.1111/j.1365-2958.1991.tb01874.x;
RA Maskell D.J., Szabo M.J., Butler P.D., Williams A.E., Moxon E.R.;
RT "Molecular analysis of a complex locus from Haemophilus influenzae involved
RT in phase-variable lipopolysaccharide biosynthesis.";
RL Mol. Microbiol. 5:1013-1022(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: To E.coli AmpG and yeast YBR220c. {ECO:0000305}.
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DR EMBL; X57315; CAA40569.1; -; Genomic_DNA.
DR EMBL; L42023; AAC22011.1; -; Genomic_DNA.
DR PIR; D64149; D64149.
DR RefSeq; NP_438514.1; NC_000907.1.
DR AlphaFoldDB; P24326; -.
DR STRING; 71421.HI_0350; -.
DR EnsemblBacteria; AAC22011; AAC22011; HI_0350.
DR KEGG; hin:HI_0350; -.
DR PATRIC; fig|71421.8.peg.369; -.
DR eggNOG; COG2814; Bacteria.
DR HOGENOM; CLU_029352_1_2_6; -.
DR OMA; ANPFYVD; -.
DR PhylomeDB; P24326; -.
DR BioCyc; HINF71421:G1GJ1-366-MON; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015295; F:solute:proton symporter activity; IBA:GO_Central.
DR GO; GO:0015835; P:peptidoglycan transport; IBA:GO_Central.
DR Gene3D; 1.20.1250.20; -; 1.
DR InterPro; IPR004752; AmpG_permease/AT-1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR12778; PTHR12778; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 4: Predicted;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..425
FT /note="Uncharacterized protein HI_0350"
FT /id="PRO_0000077914"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 84..104
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 149..169
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 174..194
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 225..245
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 295..315
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 331..351
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 395..415
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 5
FT /note="L -> F (in strain: RM 7004)"
FT VARIANT 32
FT /note="S -> L (in strain: RM 7004)"
FT VARIANT 271
FT /note="A -> S (in strain: RM 7004)"
FT VARIANT 313
FT /note="A -> S (in strain: RM 7004)"
FT VARIANT 415
FT /note="L -> W (in strain: RM 7004)"
FT VARIANT 418
FT /note="E -> K (in strain: RM 7004)"
SQ SEQUENCE 425 AA; 47354 MW; 2757C3F61B08FAB5 CRC64;
MSNSLSSQIF TRKMLICAFT GFNSGLPLFV LSQMLPVWLT DKHLSIELIG AVTGVMLPYG
LKFLWAPLLD RYFPSFLGRR RSWMLLSQVA LLILLYIISL FDPLTQLGTV ANIALLIAFF
SATQDIVLDA YRREILSDHE LGLGNTIHIN AYRIAGLIPG GLSLYLAAIY PWETVFLWTA
LCMLAGIFMT LFLAKEPKID MQQTNQPFYQ AFWIPLQEFF QRKGVIQAIG FLLFLFLYKF
GDSFATTLQT KFIYDMGFSK EDIAIVVKST ALWSSILSGL AGGMIMLKLG INRALWLFGL
VQMVTIGGFI WLAAFGHFDV ITSAELWKLG VVIAAEYIGV GLGTAAFVAF MARESNPLYT
ATQLALFTSL SALPSKVLGI LSGYVVGAVG YYQYFWFCLF LAIPGMLCLF WVAPLKQENN
KTSSV
