ID   Y3524_METAC             Reviewed;         328 AA.
AC   Q8TK90;
DT   25-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 111.
DE   RecName: Full=Putative HTH-type transcriptional regulatory protein MA_3524 {ECO:0000255|HAMAP-Rule:MF_00584};
GN   OrderedLocusNames=MA_3524;
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
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DR   EMBL; AE010299; AAM06887.1; -; Genomic_DNA.
DR   RefSeq; WP_011023440.1; NC_003552.1.
DR   AlphaFoldDB; Q8TK90; -.
DR   SMR; Q8TK90; -.
DR   STRING; 188937.MA_3524; -.
DR   EnsemblBacteria; AAM06887; AAM06887; MA_3524.
DR   GeneID; 1475418; -.
DR   KEGG; mac:MA_3524; -.
DR   HOGENOM; CLU_075726_0_0_2; -.
DR   InParanoid; Q8TK90; -.
DR   OMA; PGVVYFR; -.
DR   OrthoDB; 76134at2157; -.
DR   PhylomeDB; Q8TK90; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:UniProtKB-UniRule.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   HAMAP; MF_00584; HTH_type_cro_C1; 1.
DR   InterPro; IPR020886; Arc_TR_HTH.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   Pfam; PF01381; HTH_3; 1.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..328
FT                   /note="Putative HTH-type transcriptional regulatory protein
FT                   MA_3524"
FT                   /id="PRO_0000144855"
FT   DOMAIN          132..190
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00584"
FT   DNA_BIND        143..162
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00584"
SQ   SEQUENCE   328 AA;  36458 MW;  45D13BE362D8AB0F CRC64;
     MTKEVLIHQI IDVLSRAGFA LSDRCNIRPR SFDVAARKDE TLLLCKVLFN IDGLNEETAR
     EMKYLAEYLG GSAIVVGAKT RDQMLEDSVV YMRYDILALN VQTLYDYFVE NIKPLVSAAP
     GGLYISIEGD LLKKARTDQS MSLGTLASMV GVSRRTISKY EEEGMDASID VVLQLEDIFG
     VELARPIDIL KSCGSRKPRK KAEPEKEDPQ VKHNALLPED LILNTISMLG YDVLPTAQAP
     FKAISRDKSS VILTGVSEFN TTVVKRAHLM SSISCITETQ SVFIINGRSK LKSVENTALI
     EKKELDKISD SQELLEFIEE RKDTNSGA