CARD6_HUMAN
ID CARD6_HUMAN Reviewed; 1037 AA.
AC Q9BX69; Q52LR2;
DT 02-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Caspase recruitment domain-containing protein 6;
GN Name=CARD6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT LEU-86.
RA Bertin J.;
RT "CARD6: a novel caspase recruitment domain (CARD) protein that regulates
RT apoptosis.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-154 AND SER-985, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in apoptosis.
CC -!- INTERACTION:
CC Q9BX69; O43353: RIPK2; NbExp=2; IntAct=EBI-14405242, EBI-358522;
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DR EMBL; AF356193; AAK32718.1; -; mRNA.
DR EMBL; CH471119; EAW56006.1; -; Genomic_DNA.
DR EMBL; BC093825; AAH93825.1; -; mRNA.
DR CCDS; CCDS3935.1; -.
DR RefSeq; NP_115976.2; NM_032587.3.
DR AlphaFoldDB; Q9BX69; -.
DR SMR; Q9BX69; -.
DR BioGRID; 124193; 7.
DR DIP; DIP-61097N; -.
DR IntAct; Q9BX69; 3.
DR STRING; 9606.ENSP00000254691; -.
DR GlyGen; Q9BX69; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BX69; -.
DR PhosphoSitePlus; Q9BX69; -.
DR BioMuta; CARD6; -.
DR DMDM; 209572595; -.
DR EPD; Q9BX69; -.
DR jPOST; Q9BX69; -.
DR MassIVE; Q9BX69; -.
DR MaxQB; Q9BX69; -.
DR PaxDb; Q9BX69; -.
DR PeptideAtlas; Q9BX69; -.
DR PRIDE; Q9BX69; -.
DR ProteomicsDB; 79369; -.
DR Antibodypedia; 23154; 318 antibodies from 36 providers.
DR DNASU; 84674; -.
DR Ensembl; ENST00000254691.10; ENSP00000254691.5; ENSG00000132357.14.
DR GeneID; 84674; -.
DR KEGG; hsa:84674; -.
DR MANE-Select; ENST00000254691.10; ENSP00000254691.5; NM_032587.4; NP_115976.2.
DR UCSC; uc003jmg.4; human.
DR CTD; 84674; -.
DR DisGeNET; 84674; -.
DR GeneCards; CARD6; -.
DR HGNC; HGNC:16394; CARD6.
DR HPA; ENSG00000132357; Low tissue specificity.
DR MIM; 609986; gene.
DR neXtProt; NX_Q9BX69; -.
DR OpenTargets; ENSG00000132357; -.
DR PharmGKB; PA26076; -.
DR VEuPathDB; HostDB:ENSG00000132357; -.
DR eggNOG; ENOG502SDCX; Eukaryota.
DR GeneTree; ENSGT00940000162106; -.
DR HOGENOM; CLU_008197_0_0_1; -.
DR InParanoid; Q9BX69; -.
DR OMA; WCFPDSD; -.
DR OrthoDB; 136523at2759; -.
DR PhylomeDB; Q9BX69; -.
DR TreeFam; TF335271; -.
DR PathwayCommons; Q9BX69; -.
DR SignaLink; Q9BX69; -.
DR BioGRID-ORCS; 84674; 12 hits in 1076 CRISPR screens.
DR ChiTaRS; CARD6; human.
DR GenomeRNAi; 84674; -.
DR Pharos; Q9BX69; Tbio.
DR PRO; PR:Q9BX69; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9BX69; protein.
DR Bgee; ENSG00000132357; Expressed in epithelial cell of pancreas and 168 other tissues.
DR ExpressionAtlas; Q9BX69; baseline and differential.
DR Genevisible; Q9BX69; HS.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR Gene3D; 1.10.533.10; -; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR Pfam; PF00619; CARD; 1.
DR SMART; SM00114; CARD; 1.
DR SUPFAM; SSF47986; SSF47986; 1.
DR PROSITE; PS50209; CARD; 1.
PE 1: Evidence at protein level;
KW Acetylation; Apoptosis; Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..1037
FT /note="Caspase recruitment domain-containing protein 6"
FT /id="PRO_0000144079"
FT DOMAIN 3..94
FT /note="CARD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00046"
FT REGION 235..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 669..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..1037
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 235..253
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 254..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..989
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 990..1014
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 154
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 985
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 86
FT /note="S -> L (in dbSNP:rs10512747)"
FT /evidence="ECO:0000269|Ref.1"
FT /id="VAR_046689"
FT VARIANT 93
FT /note="R -> K (in dbSNP:rs7715491)"
FT /id="VAR_046690"
FT VARIANT 395
FT /note="M -> K (in dbSNP:rs3812030)"
FT /id="VAR_046691"
FT VARIANT 426
FT /note="D -> V (in dbSNP:rs3812031)"
FT /id="VAR_046692"
FT VARIANT 575
FT /note="A -> D (in dbSNP:rs36085996)"
FT /id="VAR_046693"
FT VARIANT 576
FT /note="I -> V (in dbSNP:rs323562)"
FT /id="VAR_046694"
SQ SEQUENCE 1037 AA; 116468 MW; 366E64BE7AFF164C CRC64;
MATESTPSEI IERERKKLLE ILQHDPDSIL DTLTSRRLIS EEEYETLENV TDLLKKSRKL
LILVQKKGEA TCQHFLKCLF STFPQSAAIC GLRHEVLKHE NTVPPQSMGA SSNSEDAFSP
GIKQPEAPEI TVFFSEKEHL DLETSEFFRD KKTSYRETAL SARKNEKEYD TPEVTLSYSV
EKVGCEVPAT ITYIKDGQRY EELDDSLYLG KEEYLGSVDT PEDAEATVEE EVYDDPEHVG
YDGEEDFENS ETTEFSGEEP SYEGSETSLS LEEEQEKSIE ERKKVFKDVL LCLNMDRSRK
VLPDFVKQFS LDRGCKWTPE SPGDLAWNFL MKVQARDVTA RDSILSHKVL DEDSKEDLLA
GVENLEIRDI QTINPLDVLC ATMLCSDSSL QRQVMSNMYQ CQFALPLLLP DAENNKSILM
LGAMKDIVKK QSTQFSGGPT EDTEKFLTLM KMPVISFVRL GYCSFSKSRI LNTLLSPAQL
KLHKIFLHQD LPLLVLPRQI SDGLVEITWC FPDSDDRKEN PFFQKPVALA NLRGNLESFW
TQFGFLMEVS SAVFFFTDCL GEKEWDLLMF LGEAAIERCY FVLSSQARES EEAQIFQRIL
NLKPAQLLFW ERGDAGDRRK NMEGLQAALQ EVMFSSCLRC VSVEDMAALA RELGIQVDED
FENTQRIQVS SGENMAGTAE GEGQQRHSQL KSSSKSQALM PIQEPGTQCE LSQNLQNLYG
TPVFRPVLEN SWLFPTRIGG NFNHVSLKAS WVMGRPFGSE QRPKWFHPLP FQNAGAQGRG
KSFGIQSFHP QIFYSGERFM KFSRVARGCH SNGTFGRLPR PICQHVQACP ERPQMMGTLE
RSRAVASKIG HSYSLDSQPA RAVGKPWPQQ ACTRVTELTE ATGKLIRTSH IGKPHPQSFQ
PAAATQKLRP ASQQGVQMKT QGGASNPALQ IGSHPMCKSS QFKSDQSNPS TVKHSQPKPF
HSVPSQPKSS QTKSCQSQPS QTKPSPCKST QPKPSQPWPP QSKPSQPRPP QPKSSSTNPS
QAKAHHSKAG QKRGGKH
