Y3556_DROME
ID Y3556_DROME Reviewed; 595 AA.
AC Q9W4K2; B5RJ69; Q8T0N7;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Uncharacterized protein CG3556;
DE Flags: Precursor;
GN ORFNames=CG3556;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF45949.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF45949.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAL39297.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND RNA EDITING OF POSITION 572.
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL39297.1}; TISSUE=Head;
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Booth B., Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E.,
RA George R.A., Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G.,
RA Miranda A., Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S.,
RA Patel S., Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M.;
RL Submitted (SEP-2008) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP RNA EDITING OF POSITION 572.
RX PubMed=17018572; DOI=10.1261/rna.254306;
RA Stapleton M., Carlson J.W., Celniker S.E.;
RT "RNA editing in Drosophila melanogaster: new targets and functional
RT consequences.";
RL RNA 12:1922-1932(2006).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- RNA EDITING: Modified_positions=572 {ECO:0000269|PubMed:17018572,
CC ECO:0000269|Ref.3}; Note=Partially edited. Target of Adar.
CC {ECO:0000269|PubMed:17018572};
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DR EMBL; AE014298; AAF45949.1; -; Genomic_DNA.
DR EMBL; AY069152; AAL39297.1; -; mRNA.
DR EMBL; BT044343; ACH92408.1; -; mRNA.
DR RefSeq; NP_001245529.1; NM_001258600.2.
DR RefSeq; NP_572164.2; NM_131936.3.
DR AlphaFoldDB; Q9W4K2; -.
DR SMR; Q9W4K2; -.
DR BioGRID; 57897; 1.
DR STRING; 7227.FBpp0301042; -.
DR GlyGen; Q9W4K2; 11 sites.
DR PaxDb; Q9W4K2; -.
DR DNASU; 31380; -.
DR EnsemblMetazoa; FBtr0070674; FBpp0070642; FBgn0029708.
DR EnsemblMetazoa; FBtr0308916; FBpp0301042; FBgn0029708.
DR GeneID; 31380; -.
DR KEGG; dme:Dmel_CG3556; -.
DR UCSC; CG3556-RA; d. melanogaster.
DR FlyBase; FBgn0029708; CG3556.
DR VEuPathDB; VectorBase:FBgn0029708; -.
DR eggNOG; ENOG502QQHG; Eukaryota.
DR GeneTree; ENSGT00530000063370; -.
DR HOGENOM; CLU_032349_0_0_1; -.
DR InParanoid; Q9W4K2; -.
DR OMA; PEHQTIG; -.
DR OrthoDB; 1233171at2759; -.
DR PhylomeDB; Q9W4K2; -.
DR Reactome; R-DME-6798695; Neutrophil degranulation.
DR Reactome; R-DME-9758881; Uptake of dietary cobalamins into enterocytes.
DR Reactome; R-DME-9758890; Transport of RCbl within the body.
DR BioGRID-ORCS; 31380; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 31380; -.
DR PRO; PR:Q9W4K2; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0029708; Expressed in second segment of antenna (Drosophila) and 8 other tissues.
DR ExpressionAtlas; Q9W4K2; baseline and differential.
DR Genevisible; Q9W4K2; DM.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031419; F:cobalamin binding; IBA:GO_Central.
DR GO; GO:0015889; P:cobalamin transport; IBA:GO_Central.
DR InterPro; IPR002157; Cbl-bd_prot.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR Pfam; PF01122; Cobalamin_bind; 1.
DR SUPFAM; SSF48239; SSF48239; 1.
PE 2: Evidence at transcript level;
KW Glycoprotein; Reference proteome; RNA editing; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..595
FT /note="Uncharacterized protein CG3556"
FT /evidence="ECO:0000255"
FT /id="PRO_0000337157"
FT REGION 61..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 141..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..160
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 144
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 187
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 205
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 389
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 480
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 492
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 506
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 572
FT /note="I -> V (in RNA edited version)"
FT /evidence="ECO:0000269|PubMed:17018572"
SQ SEQUENCE 595 AA; 65084 MW; F82A13E334C69CD7 CRC64;
MLSLSSPPWL LLLVLFFFAN GSATVVSLAE NVTLATLPST SPISVSFSTT SSVVAPISTE
LENQTASSSN LNTNNEASDE QTGNSNSNTS SHSRNINGLP SSNSNIDNAN SNSSSVSSLS
TTTSAISGVD QQESLILATP TALNGSGTPP EHQTIGQAPP TKGEQEAILR ALDWLKEKRA
SDYGWGNDTH VVILAKELSG GRDPNDSVDG HVQVIQELED TLSVKEMEIE ILAMLDRHHT
LPKPLDLDKL ARYVLALGSL CKDPKHFHGH DLVATLQHHE PAQDIEFALT TLSACSSAAH
VRKRQIRRLL DIASGVTDQS VDAIAMVILA LRCIVTDHRH RHLQHFVRRP ARGLATLQDQ
RGSFGSLRST ALAMQALQDL EYDPAGHWNR TAASRYILSR QRADGGWSEE PLQDGQEPDI
GVGLTADIIL ALGWKGLGAV RALQCDHVIR ESSDPTENGE PKLAVPFGLS SSAEESDAKN
ISYTYTLWVG SNVTESFSLS LVSPKNTSFF KAMTQAAEMD PRFIFEAREW PNGHYVHTLY
GKKEEPRGYH YWLLYRLPEL PDPNNTPGNQ LIAPVGVDEL MVEDGEHYLY WYKKL
