ID   Y3563_MYCPA             Reviewed;         313 AA.
AC   Q73U05;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 80.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MAP_3563;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MAP_3563;
OS   Mycolicibacterium paratuberculosis (strain ATCC BAA-968 / K-10)
OS   (Mycobacterium paratuberculosis).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium avium complex (MAC).
OX   NCBI_TaxID=262316;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-968 / K-10;
RX   PubMed=16116077; DOI=10.1073/pnas.0505662102;
RA   Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N.,
RA   Kanjilal S., Kapur V.;
RT   "The complete genome sequence of Mycobacterium avium subspecies
RT   paratuberculosis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AE016958; AAS06113.1; -; Genomic_DNA.
DR   RefSeq; WP_003879067.1; NC_002944.2.
DR   AlphaFoldDB; Q73U05; -.
DR   SMR; Q73U05; -.
DR   STRING; 262316.MAP_3563; -.
DR   EnsemblBacteria; AAS06113; AAS06113; MAP_3563.
DR   KEGG; mpa:MAP_3563; -.
DR   PATRIC; fig|262316.17.peg.3793; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; QAVRTHY; -.
DR   Proteomes; UP000000580; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..313
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MAP_3563"
FT                   /id="PRO_0000361180"
FT   BINDING         139
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         168..169
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   313 AA;  34152 MW;  2E96E5E30CDBD7E5 CRC64;
     MTDLDSSLPP SVRTAGDSWT ITELVGATAL GVAAARAAET AGPDPLIRDE FAGLLVSSAS
     PAWARLADPE LSWLDDDPHG KRAHRVGIDY QAVRTHYFDE YFDGALRAGI RQVVILAAGL
     DSRAYRLNWP AGTTVYEIDQ PKVLEYKTET LQRHGATPAA VRRPVPVDLR DDWPAALTAA
     GFQAARPTAW LAEGLLPYLP SDAQDRLFEM VTALSAAGSQ VAVEVFGMNS RSNAQRWLRM
     RERLGLDVNV AALTYHEPDR SDAAAWLARH GWRVHSVDNR DEMARLGRPV PEDLSDEAVR
     STLLRAHLGG STG