ID   Y357_HAEIN              Reviewed;         314 AA.
AC   P44658;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=Putative thiamine biosynthesis protein HI_0357;
GN   OrderedLocusNames=HI_0357;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: Probably involved in thiamine biosynthesis.
CC   -!- SIMILARITY: Belongs to the NMT1/THI5 family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22016.1; -; Genomic_DNA.
DR   PIR; C64063; C64063.
DR   RefSeq; NP_438519.1; NC_000907.1.
DR   RefSeq; WP_005693803.1; NC_000907.1.
DR   AlphaFoldDB; P44658; -.
DR   SMR; P44658; -.
DR   STRING; 71421.HI_0357; -.
DR   TCDB; 3.A.1.17.3; the atp-binding cassette (abc) superfamily.
DR   EnsemblBacteria; AAC22016; AAC22016; HI_0357.
DR   KEGG; hin:HI_0357; -.
DR   PATRIC; fig|71421.8.peg.375; -.
DR   eggNOG; COG0715; Bacteria.
DR   HOGENOM; CLU_028871_6_2_6; -.
DR   OMA; DWFVNPD; -.
DR   PhylomeDB; P44658; -.
DR   BioCyc; HINF71421:G1GJ1-371-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0009228; P:thiamine biosynthetic process; IBA:GO_Central.
DR   InterPro; IPR027939; NMT1/THI5.
DR   InterPro; IPR015168; SsuA/THI5.
DR   PANTHER; PTHR31528; PTHR31528; 1.
DR   Pfam; PF09084; NMT1; 1.
PE   1: Evidence at protein level;
KW   Reference proteome; Thiamine biosynthesis.
FT   CHAIN           1..314
FT                   /note="Putative thiamine biosynthesis protein HI_0357"
FT                   /id="PRO_0000211625"
SQ   SEQUENCE   314 AA;  34961 MW;  BE86F4303D253C16 CRC64;
     MKTIIRYFSF VMGLMLTLPS FAKEKISIML DWYVNPDHAA IIVAQQKGFF EKNNLEVEII
     EPADPALPPK LAAAEKVDLA VSYQPQLYQQ VAEGLPLVRV GSLISNPLNS VVVLKKSNLK
     SLADLKGKKV GYSVSGFEDG LLDTMLHSIG LSNKDVELVN VNWSLSPSLL TGQVDAVIGA
     FRNFELNQLA LEKQEGIAFF PEQYGVPAYD ELILVANKNS VTDKKTSAFL TALEQATSYL
     QAHPNEAWQA FVSYKPNELN TPLNQLAWKD TLPFLANKPR QLDAKRYQQM AEFMQQKGLI
     PKALALKEYA VEIE