ID   Y357_MYCMM              Reviewed;         310 AA.
AC   B2HLS5;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MMAR_0357;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MMAR_0357;
OS   Mycobacterium marinum (strain ATCC BAA-535 / M).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=216594;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-535 / M;
RX   PubMed=18403782; DOI=10.1101/gr.075069.107;
RA   Stinear T.P., Seemann T., Harrison P.F., Jenkin G.A., Davies J.K.,
RA   Johnson P.D., Abdellah Z., Arrowsmith C., Chillingworth T., Churcher C.,
RA   Clarke K., Cronin A., Davis P., Goodhead I., Holroyd N., Jagels K.,
RA   Lord A., Moule S., Mungall K., Norbertczak H., Quail M.A.,
RA   Rabbinowitsch E., Walker D., White B., Whitehead S., Small P.L., Brosch R.,
RA   Ramakrishnan L., Fischbach M.A., Parkhill J., Cole S.T.;
RT   "Insights from the complete genome sequence of Mycobacterium marinum on the
RT   evolution of Mycobacterium tuberculosis.";
RL   Genome Res. 18:729-741(2008).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACC38824.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000854; ACC38824.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; B2HLS5; -.
DR   SMR; B2HLS5; -.
DR   STRING; 216594.MMAR_0357; -.
DR   EnsemblBacteria; ACC38824; ACC38824; MMAR_0357.
DR   KEGG; mmi:MMAR_0357; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   Proteomes; UP000001190; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..310
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MMAR_0357"
FT                   /id="PRO_0000361169"
FT   BINDING         132
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         161..162
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   310 AA;  34565 MW;  2EF3BB1E5928B24E CRC64;
     MRTHDDTWDI RTSVGATAVM VAAARAVETS KPEPLIRDPY ARMLVTNANA GVIWEAMLDQ
     EMVAKVEAID AETAATVEHM RSYQAVRTNF FDTYFADAVA AGIRQVVILA SGLDSRAYRL
     DWPAGTTVYE IDQPQVLAYK SATLAENGVT PAAERREVAI DLRQDWPSAL RAAGFDPSAR
     TAWLAEGLLM YLPAEAQDRL FTQIGELSCA GSRIAAETAG NHADERREQM RERFRKVAQT
     LGLEQTIDVH ELIYHDPDRA LLGQWLNEHG WRANAQNACD EMHRVGRWVE GVPMADDKQA
     YSEFVTAERL