ID   Y3589_DICDI             Reviewed;         386 AA.
AC   Q557F7; Q86HY5;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=SET and MYND domain-containing protein DDB_G0273589;
DE            EC=2.1.1.-;
GN   ORFNames=DDB_G0273589;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable methyltransferase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; AAFI02000011; EAL70485.1; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70844.1; -; Genomic_DNA.
DR   RefSeq; XP_644411.1; XM_639319.1.
DR   RefSeq; XP_644839.1; XM_639747.1.
DR   AlphaFoldDB; Q557F7; -.
DR   SMR; Q557F7; -.
DR   STRING; 44689.DDB0220708; -.
DR   PaxDb; Q557F7; -.
DR   EnsemblProtists; EAL70485; EAL70485; DDB_G0273589.
DR   EnsemblProtists; EAL70844; EAL70844; DDB_G0273253.
DR   GeneID; 8618941; -.
DR   GeneID; 8619036; -.
DR   KEGG; ddi:DDB_G0273253; -.
DR   KEGG; ddi:DDB_G0273589; -.
DR   dictyBase; DDB_G0273253; -.
DR   dictyBase; DDB_G0273589; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_702894_0_0_1; -.
DR   InParanoid; Q557F7; -.
DR   OMA; LNGFEMT; -.
DR   PhylomeDB; Q557F7; -.
DR   Reactome; R-DDI-3214841; PKMTs methylate histone lysines.
DR   PRO; PR:Q557F7; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0034968; P:histone lysine methylation; IBA:GO_Central.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR002893; Znf_MYND.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01360; ZF_MYND_1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Metal-binding; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase; Zinc; Zinc-finger.
FT   CHAIN           1..386
FT                   /note="SET and MYND domain-containing protein DDB_G0273589"
FT                   /id="PRO_0000389432"
FT   DOMAIN          6..294
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   ZN_FING         51..94
FT                   /note="MYND-type"
FT   COILED          136..171
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   386 AA;  44685 MW;  ADAB950283F51CE7 CRC64;
     MFKSFNGLEL KSSENEGRYL IATRDIQIGE DLLKCKSYFA VTSETLKTTS CFNCIKQLPS
     VIKLSLKCNQ CNEIWYCNEQ CKNENINKHQ HYECKFYKKL KSPKLKVYPN FDIETFTEIR
     MIVGLLSRYY QDILLNNKFI EQQLNNNNNN NNDNEQLTNT LDDVFDLVEN QVTEESNPAA
     KERIDSIVEF ISELFNLVLL GSTTTKSIIN NDDKIEMIRK INEKSRSIIH KTRCNQFGIW
     TKNDKCIGVA VSPSSSYFNH SCIPNCTDVR DGSNMTFKSL YPIKKGDQLT ISYIELDQPI
     QDRKDELKYG YYFDCICPRC NGDSNSIDSM DNWISKFYCS QKKCTGLYYS KPMIPILNTL
     TSNHEIQLSC SNCNNINIVT PSFFNK