ID   Y358_STRP1              Reviewed;         229 AA.
AC   Q9A1B9; Q490P8;
DT   14-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 128.
DE   RecName: Full=Uncharacterized membrane protein SPy_0358/M5005_Spy0301;
GN   OrderedLocusNames=SPy_0358, M5005_Spy0301;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BI1 family. {ECO:0000305}.
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DR   EMBL; AE004092; AAK33404.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ50920.1; -; Genomic_DNA.
DR   RefSeq; NP_268683.1; NC_002737.2.
DR   AlphaFoldDB; Q9A1B9; -.
DR   SMR; Q9A1B9; -.
DR   STRING; 1314.HKU360_00337; -.
DR   PaxDb; Q9A1B9; -.
DR   EnsemblBacteria; AAK33404; AAK33404; SPy_0358.
DR   KEGG; spy:SPy_0358; -.
DR   KEGG; spz:M5005_Spy0301; -.
DR   PATRIC; fig|160490.10.peg.309; -.
DR   HOGENOM; CLU_058671_1_2_9; -.
DR   OMA; SHNAYAE; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR006214; Bax_inhibitor_1-related.
DR   PANTHER; PTHR23291; PTHR23291; 1.
DR   Pfam; PF01027; Bax1-I; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..229
FT                   /note="Uncharacterized membrane protein
FT                   SPy_0358/M5005_Spy0301"
FT                   /id="PRO_0000179113"
FT   TRANSMEM        21..41
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        56..76
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        141..161
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   229 AA;  24990 MW;  35A85F5AFF0D9137 CRC64;
     MNDHVIYTQS DVGLNQFFAK IYSLVGMGVG LSAFVSYLML YPFRENLISI LVNQPMIYYG
     AAIIELILVF VASSAARKNT PAALPIFLIY SALNGFTLSF IIVAYAQTTV FQAFLSSAAV
     FFAMSIIGVK TKRDMSGLRK AMFAALIGVV VASLINLFIG SGMMSYVISV ISVLIFSGLI
     ASDNQMIKRV YQATNGQVGD GWAVAMALSL YLDFINLFIS LLRIFGRND