ID   Y3591_DICDI             Reviewed;         413 AA.
AC   Q557F6;
DT   24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=SET and MYND domain-containing protein DDB_G0273591;
DE            EC=2.1.1.-;
GN   ORFNames=DDB_G0273591;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Probable methyltransferase. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase
CC       superfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
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DR   EMBL; AAFI02000011; EAL70486.1; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70914.1; -; Genomic_DNA.
DR   RefSeq; XP_644412.1; XM_639320.1.
DR   RefSeq; XP_644838.1; XM_639746.1.
DR   AlphaFoldDB; Q557F6; -.
DR   SMR; Q557F6; -.
DR   STRING; 44689.DDB0220707; -.
DR   PaxDb; Q557F6; -.
DR   EnsemblProtists; EAL70486; EAL70486; DDB_G0273591.
DR   EnsemblProtists; EAL70914; EAL70914; DDB_G0273393.
DR   GeneID; 8618940; -.
DR   GeneID; 8619037; -.
DR   KEGG; ddi:DDB_G0273393; -.
DR   KEGG; ddi:DDB_G0273591; -.
DR   dictyBase; DDB_G0273393; -.
DR   dictyBase; DDB_G0273591; -.
DR   eggNOG; KOG2084; Eukaryota.
DR   HOGENOM; CLU_702894_0_0_1; -.
DR   InParanoid; Q557F6; -.
DR   OMA; HACVANC; -.
DR   PhylomeDB; Q557F6; -.
DR   Reactome; R-DDI-3214841; PKMTs methylate histone lysines.
DR   PRO; PR:Q557F6; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0034968; P:histone lysine methylation; IBA:GO_Central.
DR   Gene3D; 2.170.270.10; -; 1.
DR   InterPro; IPR001214; SET_dom.
DR   InterPro; IPR046341; SET_dom_sf.
DR   InterPro; IPR002893; Znf_MYND.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   SUPFAM; SSF82199; SSF82199; 1.
DR   PROSITE; PS50280; SET; 1.
DR   PROSITE; PS01360; ZF_MYND_1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Metal-binding; Methyltransferase; Reference proteome;
KW   S-adenosyl-L-methionine; Transferase; Zinc; Zinc-finger.
FT   CHAIN           1..413
FT                   /note="SET and MYND domain-containing protein DDB_G0273591"
FT                   /id="PRO_0000389433"
FT   DOMAIN          6..311
FT                   /note="SET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00190"
FT   ZN_FING         51..95
FT                   /note="MYND-type"
FT   REGION          205..232
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          216..243
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   413 AA;  47881 MW;  859E1F6D969CB994 CRC64;
     MFKSFDGLKL SNSELEGRYI IANRDIDIGE SILKCKSYFA VTCEDFKKNS CYNCIKLIKS
     PSPQQVPRCF GCNEVWYCSE KCKQDNQAKH QHYECAFFNN IKSPKLIQNS KLDFDSYSEI
     RIILGLLSRY YQDKLLNNKF NSSIIINNQQ DDEEDFIKDT LDGVLDLVEN DINEETNSVA
     KEYIDNIIEY IINILKLTIN NNSNDNNNNN NNNNNNNNNN NNNNNNNNNN NNNNIEELIK
     LIRPLIQKVR CNQFGIWTKN DKCIGMAVSP SSSYFNHSCI PNCESVRDGS DMTFKSLFPI
     KKGDQINISY LALDKSTKRR RDYLKFGYYF HCQCPRCNST DIDPTGKLED SLDNWISKFY
     CHQKKCTGLY YSKLKLSLQS LTNIDNHEIQ LSCSTCNDQL IVNSNFYLNK PNY