ID   CARD_MYCTO              Reviewed;         162 AA.
AC   P9WJG2; F2GJS9; L0TFY0; O53568; Q7D585;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=RNA polymerase-binding transcription factor CarD;
GN   Name=carD; OrderedLocusNames=MT3689;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Controls rRNA transcription by binding to the RNA polymerase
CC       (RNAP). Required for replication and persistence during infection of
CC       mice (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CarD family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK48047.1; -; Genomic_DNA.
DR   PIR; H70803; H70803.
DR   RefSeq; WP_003419482.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJG2; -.
DR   SMR; P9WJG2; -.
DR   EnsemblBacteria; AAK48047; AAK48047; MT3689.
DR   GeneID; 64258344; -.
DR   GeneID; 66743455; -.
DR   KEGG; mtc:MT3689; -.
DR   PATRIC; fig|83331.31.peg.3972; -.
DR   HOGENOM; CLU_048259_1_2_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   Gene3D; 1.20.58.1290; -; 1.
DR   InterPro; IPR036101; CarD-like/TRCF_dom_sf.
DR   InterPro; IPR003711; CarD-like/TRCF_domain.
DR   InterPro; IPR042215; CarD-like_C.
DR   Pfam; PF02559; CarD_CdnL_TRCF; 1.
DR   SMART; SM01058; CarD_TRCF; 1.
DR   SUPFAM; SSF141259; SSF141259; 1.
PE   3: Inferred from homology;
KW   Virulence.
FT   CHAIN           1..162
FT                   /note="RNA polymerase-binding transcription factor CarD"
FT                   /id="PRO_0000427835"
SQ   SEQUENCE   162 AA;  17907 MW;  15F27E0732FD6AD7 CRC64;
     MIFKVGDTVV YPHHGAALVE AIETRTIKGE QKEYLVLKVA QGDLTVRVPA ENAEYVGVRD
     VVGQEGLDKV FQVLRAPHTE EPTNWSRRYK ANLEKLASGD VNKVAEVVRD LWRRDQERGL
     SAGEKRMLAK ARQILVGELA LAESTDDAKA ETILDEVLAA AS