ID   Y3618_MYCTA             Reviewed;         322 AA.
AC   A5U8Q4;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Uncharacterized tRNA/rRNA methyltransferase MRA_3618;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MRA_3618;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family. {ECO:0000305}.
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DR   EMBL; CP000611; ABQ75404.1; -; Genomic_DNA.
DR   RefSeq; WP_003900107.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U8Q4; -.
DR   SMR; A5U8Q4; -.
DR   STRING; 419947.MRA_3618; -.
DR   EnsemblBacteria; ABQ75404; ABQ75404; MRA_3618.
DR   KEGG; mra:MRA_3618; -.
DR   eggNOG; COG0566; Bacteria.
DR   HOGENOM; CLU_021322_0_0_11; -.
DR   OMA; QVPPYEY; -.
DR   OrthoDB; 1422015at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   PANTHER; PTHR46429; PTHR46429; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   SUPFAM; SSF75217; SSF75217; 1.
DR   TIGRFAMs; TIGR00186; rRNA_methyl_3; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..322
FT                   /note="Uncharacterized tRNA/rRNA methyltransferase
FT                   MRA_3618"
FT                   /id="PRO_0000379582"
FT   REGION          1..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         261
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         281
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         290
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   322 AA;  34010 MW;  C02D12F75646D71D CRC64;
     MPGNSRRRGA VRKSGTKKGA GVGSGGQRRR GLEGRGPTPP AHLRPHHPAA KRARAQPRRP
     VKRADETETV LGRNPVLECL RAGVPATALY VALGTEADER LTECVARAAD SGIAIVELLR
     ADLDRMTANH LHQGIALQVP PYNYAHPDDL LAAALDQPPA LLVALDNLSD PRNLGAIVRS
     VAAFGGHGVL IPQRRSASVT AVAWRTSAGA AARIPVARAT NLTRTLKGWA DRGVRVIGLD
     AGGGTALDDV DGTDSLVVVV GSEGKGLSRL VRQNCDEVVS IPMAAQAESL NASVAAGVVL
     AEIARQRRRP REPREQTQNR MI