Y3629_DICDI
ID Y3629_DICDI Reviewed; 543 AA.
AC Q54QU8;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Probable zinc transporter protein DDB_G0283629;
GN ORFNames=DDB_G0283629;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May be involved in zinc transport from the cytoplasm to
CC either intracellular organelles or extracellular spaces. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cation diffusion facilitator (CDF)
CC transporter (TC 2.A.4) family. SLC30A subfamily. {ECO:0000305}.
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DR EMBL; AAFI02000056; EAL65581.1; -; Genomic_DNA.
DR RefSeq; XP_638925.1; XM_633833.1.
DR AlphaFoldDB; Q54QU8; -.
DR SMR; Q54QU8; -.
DR STRING; 44689.DDB0238287; -.
DR PaxDb; Q54QU8; -.
DR EnsemblProtists; EAL65581; EAL65581; DDB_G0283629.
DR GeneID; 8624164; -.
DR KEGG; ddi:DDB_G0283629; -.
DR dictyBase; DDB_G0283629; zntA.
DR eggNOG; KOG1482; Eukaryota.
DR HOGENOM; CLU_013430_0_1_1; -.
DR InParanoid; Q54QU8; -.
DR OMA; FYFMSIN; -.
DR PhylomeDB; Q54QU8; -.
DR Reactome; R-DDI-264876; Insulin processing.
DR Reactome; R-DDI-435368; Zinc efflux and compartmentalization by the SLC30 family.
DR PRO; PR:Q54QU8; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0000331; C:contractile vacuole; IDA:dictyBase.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0140220; C:pathogen-containing vacuole; IDA:dictyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; ISS:dictyBase.
DR GO; GO:0042742; P:defense response to bacterium; IDA:dictyBase.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0006829; P:zinc ion transport; IMP:dictyBase.
DR Gene3D; 1.20.1510.10; -; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR Pfam; PF01545; Cation_efflux; 1.
DR SUPFAM; SSF160240; SSF160240; 1.
DR SUPFAM; SSF161111; SSF161111; 1.
DR TIGRFAMs; TIGR01297; CDF; 1.
PE 3: Inferred from homology;
KW Ion transport; Membrane; Metal-binding; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport; Zinc; Zinc transport.
FT CHAIN 1..543
FT /note="Probable zinc transporter protein DDB_G0283629"
FT /id="PRO_0000385369"
FT TOPO_DOM 1..186
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 187..207
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 208..216
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..251
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 252..272
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 273..289
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 290..310
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 311..375
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 397..402
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 403..423
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 424..543
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 319..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..54
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..102
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..175
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 516..535
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 59836 MW; 7574DCDF32AC1392 CRC64;
MENFKNNELE SSPIINKNNS SHSINNEDNN YYSHNLEHND NNNNDNNNTI TNSHINNHDH
KHNHEHEHKH KHNHDHNHDH DHNHEEEYGH GNELEHNNDQ EHNVGNKNLL TNNNNQSKKK
KHGHSHGGGE DGSSSGGGGG RHGHGHSHGG GSGSDHNHGS SDEDDEESKP LNQLRNLDSK
KKARYSLILA LTLTTIFMVG EIVGGYFANS LAIMTDAAHL LTDIGAMFLS LFAMWISQHP
PTSSMSFGFH RAEILGALVS VLMIWALTGV LVYEAIQRIL YPPDAVDGKI MFIIASCGLF
INIIDAIILH WGSGGHGHSH GGGHGHSHGI GGGTQKKKSK KNRLLNNQGQ DIEDLGGENG
KNKKGVRNIN VHSAYIHVLG DCFQSIGVMV ASCIIWVHPH WKIADPITTL IFSVIVLGTT
IKLLRESLGV LMEGVPPEID VSEVKGDLSE IEGVTEVHDL HIWSITLGRP ALSVHLTILP
TIDPEEILSI ANKILLEDYE INHTTIQIEK PLVKDKCKDH SCPPPKPKKK KIKNDNLSSP
PNQ
