ID   CARFA_XENLA             Reviewed;         398 AA.
AC   Q7ZXV6;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Protein CDKN2AIP homolog A;
GN   Name=cdkn2aip-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate DNA damage response and cell proliferation.
CC       {ECO:0000250|UniProtKB:Q9NXV6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q9NXV6}.
CC   -!- SIMILARITY: Belongs to the CARF family. {ECO:0000305}.
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DR   EMBL; BC044102; AAH44102.1; -; mRNA.
DR   RefSeq; NP_001079547.1; NM_001086078.1.
DR   AlphaFoldDB; Q7ZXV6; -.
DR   SMR; Q7ZXV6; -.
DR   BioGRID; 97477; 1.
DR   IntAct; Q7ZXV6; 2.
DR   DNASU; 379234; -.
DR   GeneID; 379234; -.
DR   KEGG; xla:379234; -.
DR   CTD; 379234; -.
DR   Xenbase; XB-GENE-984880; cdkn2aip.L.
DR   OrthoDB; 1524198at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 379234; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021859; XTBD.
DR   Pfam; PF11952; XTBD; 1.
DR   PROSITE; PS51827; XTBD; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..398
FT                   /note="Protein CDKN2AIP homolog A"
FT                   /id="PRO_0000324342"
FT   DOMAIN          19..124
FT                   /note="XRN2-binding (XTBD)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01171"
FT   REGION          118..245
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..150
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        151..198
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..225
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        226..242
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   398 AA;  44790 MW;  26E133EF1C38212B CRC64;
     MADDVSEFLG QNPETAAWLE LVHGECESDK LWRYRKEFIL RNLSDVCGEA EVPPPPETNH
     KALDRLLAYS MVWANHVFTG CRYPLPVMEK VLKMAENIKV TDAPTHTTRD ELVAKVKKRG
     ISSSNEGVEE EPCKKQKSSD HGERESSYIE DTISDGNVPS TSLNKREARL SAAQRTDVNT
     EFYDKSSNRR SLPVSNAKSR LNLPEEAGYK HGATQGRKSH SDIRHQTSMK GPAQSSDNAL
     KPTRRFTTEH TKERQPFFNR LYKTVAWKLV SAGGFNANLN HEELLNTCIE SLKATLEVSF
     VPLTDLADLP QNKTSQENTV CELRCKSVYL GMGCGKTMET AKAVASREAV KLFLKKKVVV
     RICKRKFNGR DVEDLVLVDE EFRPVNLPPA IKNPQEIV