ID   CARFB_XENLA             Reviewed;         413 AA.
AC   Q6PAV5;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 51.
DE   RecName: Full=Protein CDKN2AIP homolog B;
GN   Name=cdkn2aip-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May regulate DNA damage response and cell proliferation.
CC       {ECO:0000250|UniProtKB:Q9NXV6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleoplasm
CC       {ECO:0000250|UniProtKB:Q9NXV6}.
CC   -!- SIMILARITY: Belongs to the CARF family. {ECO:0000305}.
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DR   EMBL; BC060029; AAH60029.1; -; mRNA.
DR   RefSeq; NP_001083190.1; NM_001089721.1.
DR   AlphaFoldDB; Q6PAV5; -.
DR   SMR; Q6PAV5; -.
DR   DNASU; 398792; -.
DR   GeneID; 398792; -.
DR   KEGG; xla:398792; -.
DR   CTD; 398792; -.
DR   Xenbase; XB-GENE-6255427; cdkn2aip.S.
DR   OrthoDB; 1524198at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 398792; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR021859; XTBD.
DR   Pfam; PF11952; XTBD; 1.
DR   PROSITE; PS51827; XTBD; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..413
FT                   /note="Protein CDKN2AIP homolog B"
FT                   /id="PRO_0000324343"
FT   DOMAIN          21..118
FT                   /note="XRN2-binding (XTBD)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01171"
FT   REGION          118..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        118..170
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..257
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   413 AA;  46648 MW;  9984484DB62584BE CRC64;
     MASEDEVSEF LGQNPETAAW LERVRGQCES DKLWRYRREF ILRNLSDVCG EGEIPPPPET
     NHKELDRLLA YSMVWANHVF TGCRYPIQVI EKVLKMAENI KVTDAPTHTT RDELVAKVKK
     RGNSSSNEGV EELPRKKKKS NDHGARESSY IDDTVEIRNQ PGDARERSSG KICDGYIPST
     SLNKREAHSR TDVNTEFYEE SGNGRPLPVS KAKSSLNPPE EAGYKHAATQ GRKSHSDSRY
     QTAVKGPSQS SDNALKPTRR FTTEHTKERQ PFFNRLYKTV AWKLVSAGGF NANLNHEELL
     NTSIESLKAT LEIAFVPLKD LADFPQNKTS QENTVCELRC KSVYLGMGCG KTMDTAKAVA
     FREAVKLFLK KKVVVRICRR KFNGRDVEDL VLVDEEFRPP NLPPAVKNPH ELV