ID   Y3659_MYCTU             Reviewed;         352 AA.
AC   P9WMT3; L0TEU9; Q6MWU9; Q7D547;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Putative conjugal transfer protein Rv3659c;
GN   OrderedLocusNames=Rv3659c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12657046; DOI=10.1046/j.1365-2958.2003.03425.x;
RA   Sassetti C.M., Boyd D.H., Rubin E.J.;
RT   "Genes required for mycobacterial growth defined by high density
RT   mutagenesis.";
RL   Mol. Microbiol. 48:77-84(2003).
RN   [3]
RP   INDUCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16573683; DOI=10.1111/j.1365-2958.2006.05102.x;
RA   Walters S.B., Dubnau E., Kolesnikova I., Laval F., Daffe M., Smith I.;
RT   "The Mycobacterium tuberculosis PhoPR two-component system regulates genes
RT   essential for virulence and complex lipid biosynthesis.";
RL   Mol. Microbiol. 60:312-330(2006).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- INDUCTION: Expressed at a higher level in a phoP disruption mutant than
CC       in the wild type. {ECO:0000269|PubMed:16573683}.
CC   -!- DISRUPTION PHENOTYPE: Not essential for growth.
CC       {ECO:0000269|PubMed:12657046}.
CC   -!- SIMILARITY: Belongs to the GSP E family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46482.1; -; Genomic_DNA.
DR   PIR; D70788; D70788.
DR   RefSeq; WP_003901691.1; NC_000962.3.
DR   RefSeq; YP_178003.1; NC_000962.3.
DR   AlphaFoldDB; P9WMT3; -.
DR   SMR; P9WMT3; -.
DR   STRING; 83332.Rv3659c; -.
DR   PaxDb; P9WMT3; -.
DR   DNASU; 885627; -.
DR   GeneID; 885627; -.
DR   KEGG; mtu:Rv3659c; -.
DR   PATRIC; fig|83332.12.peg.4079; -.
DR   TubercuList; Rv3659c; -.
DR   eggNOG; COG4962; Bacteria.
DR   OMA; HDERVIT; -.
DR   PhylomeDB; P9WMT3; -.
DR   PHI-base; PHI:7453; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022399; HlxAse/secretion_ATPase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001482; T2SS/T4SS.
DR   Pfam; PF00437; T2SSE; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03819; heli_sec_ATPase; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Conjugation; Cytoplasm; Nucleotide-binding;
KW   Reference proteome; Transport.
FT   CHAIN           1..352
FT                   /note="Putative conjugal transfer protein Rv3659c"
FT                   /id="PRO_0000390679"
FT   BINDING         160..167
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   352 AA;  36691 MW;  5B6D3ECE60F4FD80 CRC64;
     MLGDTEVLAN LRVLQTELTG AGILEPLLSA DGTTDVLVTA PDSVWVDDGN GLRRSQIRFA
     DESAVRRLAQ RLALAAGRRL DDAQPWVDGQ LTGIGVGGFA VRLHAVLPPV ATQGTCLSLR
     VLRPATQDLA ALAAAGAIDP AAAALVADIV TARLAFLVCG GTGAGKTTLL AAMLGAVSPD
     ERIVCVEDAA ELAPRHPHLV KLVARRANVE GIGEVTVRQL VRQALRMRPD RIVVGEVRGA
     EVVDLLAALN TGHEGGAGTV HANNPGEVPA RMEALGALGG LDRAALHSQL AAAVQVLLHV
     ARDRAGRRRL AEIAVLRQAE GRVQAVTVWH ADRGMSDDAA ALHDLLRSRA SA