ID   Y3660_MYCTU             Reviewed;         350 AA.
AC   P9WKX7; L0TD64; O69628; Q7D546;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Uncharacterized protein Rv3660c;
GN   OrderedLocusNames=Rv3660c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=12657046; DOI=10.1046/j.1365-2958.2003.03425.x;
RA   Sassetti C.M., Boyd D.H., Rubin E.J.;
RT   "Genes required for mycobacterial growth defined by high density
RT   mutagenesis.";
RL   Mol. Microbiol. 48:77-84(2003).
RN   [3]
RP   INDUCTION, AND FUNCTION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=16735741; DOI=10.1099/mic.0.28762-0;
RA   Slayden R.A., Knudson D.L., Belisle J.T.;
RT   "Identification of cell cycle regulators in Mycobacterium tuberculosis by
RT   inhibition of septum formation and global transcriptional analysis.";
RL   Microbiology 152:1789-1797(2006).
RN   [4]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
CC   -!- FUNCTION: May play a role in septum formation.
CC       {ECO:0000269|PubMed:16735741}.
CC   -!- INDUCTION: Induced by albendazole and thiabendazole, which inhibit the
CC       GTPase activity of FtsZ and probably septum formation.
CC       {ECO:0000269|PubMed:16735741}.
CC   -!- DISRUPTION PHENOTYPE: Essential for growth.
CC       {ECO:0000269|PubMed:12657046}.
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
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DR   EMBL; AL123456; CCP46483.1; -; Genomic_DNA.
DR   PIR; E70788; E70788.
DR   RefSeq; NP_218177.1; NC_000962.3.
DR   RefSeq; WP_003900732.1; NZ_NVQJ01000028.1.
DR   AlphaFoldDB; P9WKX7; -.
DR   SMR; P9WKX7; -.
DR   STRING; 83332.Rv3660c; -.
DR   PaxDb; P9WKX7; -.
DR   PRIDE; P9WKX7; -.
DR   DNASU; 885319; -.
DR   GeneID; 885319; -.
DR   KEGG; mtu:Rv3660c; -.
DR   PATRIC; fig|83332.111.peg.4069; -.
DR   TubercuList; Rv3660c; -.
DR   eggNOG; COG0455; Bacteria.
DR   OMA; DLDPWGG; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0009898; C:cytoplasmic side of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; HDA:MTBBASE.
DR   GO; GO:0005524; F:ATP binding; IBA:GO_Central.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0051782; P:negative regulation of cell division; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR022521; CHP03815_CpaE-like.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR03815; CpaE_hom_Actino; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..350
FT                   /note="Uncharacterized protein Rv3660c"
FT                   /id="PRO_0000390676"
SQ   SEQUENCE   350 AA;  35807 MW;  1FEA7D40836322CD CRC64;
     MLTDPGLRDE LDRVAAAVGV RVVHLGGRHP VSRKTWSAAA AVVLDHAAAD RCGRLALPRR
     THVSVLTGTE AATATWAAAI TVGAQHVLRM PEQEGELVRE LAEAAESARD DGICGAVVAV
     IGGRGGAGAS LFAVALAQAA ADALLVDLDP WAGGIDLLVG GETAPGLRWP DLALQGGRLN
     WSAVRAALPR PRGISVLSGT RRGYELDAGP VDAVIDAGRR GGVTVVCDLP RRLTDATQAA
     LDAADLVVLV SPCDVRACAA AATMAPVLTA INPNLGLVVR GPSPGGLRAA EVADVAGVPL
     LASMRAQPRL AEQLEHGGLR LRRRSVLASA ARRVLGVLPR AGSGRHGRAA