Y3679_MYCTU
ID Y3679_MYCTU Reviewed; 340 AA.
AC P9WKX5; L0TD83; O69647; P65089;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 41.
DE RecName: Full=Putative ATPase Rv3679;
GN OrderedLocusNames=Rv3679; ORFNames=MTV025.027;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA Raman K., Yeturu K., Chandra N.;
RT "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT through an interactome, reactome and genome-scale structural analysis.";
RL BMC Syst. Biol. 2:109-109(2008).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL123456; CCP46503.1; -; Genomic_DNA.
DR PIR; H70790; H70790.
DR RefSeq; NP_218196.1; NC_000962.3.
DR RefSeq; WP_003419738.1; NZ_NVQJ01000028.1.
DR PDB; 6BS3; X-ray; 2.30 A; A=1-340.
DR PDB; 6BS4; X-ray; 2.50 A; A=1-340.
DR PDB; 6BS5; X-ray; 3.10 A; A=1-340.
DR PDBsum; 6BS3; -.
DR PDBsum; 6BS4; -.
DR PDBsum; 6BS5; -.
DR AlphaFoldDB; P9WKX5; -.
DR SMR; P9WKX5; -.
DR STRING; 83332.Rv3679; -.
DR PaxDb; P9WKX5; -.
DR DNASU; 885809; -.
DR GeneID; 885809; -.
DR KEGG; mtu:Rv3679; -.
DR TubercuList; Rv3679; -.
DR eggNOG; COG0003; Bacteria.
DR OMA; EMPVQET; -.
DR PhylomeDB; P9WKX5; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR025723; Anion-transp_ATPase-like_dom.
DR InterPro; IPR016300; ATPase_ArsA/GET3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR10803; PTHR10803; 1.
DR Pfam; PF02374; ArsA_ATPase; 2.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW 3D-structure; ATP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..340
FT /note="Putative ATPase Rv3679"
FT /id="PRO_0000104143"
FT BINDING 28..35
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT HELIX 16..19
FT /evidence="ECO:0007829|PDB:6BS3"
FT STRAND 22..29
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 34..46
FT /evidence="ECO:0007829|PDB:6BS3"
FT TURN 47..49
FT /evidence="ECO:0007829|PDB:6BS3"
FT STRAND 51..56
FT /evidence="ECO:0007829|PDB:6BS3"
FT STRAND 58..60
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 62..66
FT /evidence="ECO:0007829|PDB:6BS3"
FT STRAND 77..82
FT /evidence="ECO:0007829|PDB:6BS3"
FT TURN 83..85
FT /evidence="ECO:0007829|PDB:6BS3"
FT STRAND 86..92
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 95..107
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 110..117
FT /evidence="ECO:0007829|PDB:6BS3"
FT TURN 118..120
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 121..128
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 130..146
FT /evidence="ECO:0007829|PDB:6BS3"
FT STRAND 152..155
FT /evidence="ECO:0007829|PDB:6BS4"
FT STRAND 157..162
FT /evidence="ECO:0007829|PDB:6BS3"
FT TURN 166..168
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 169..172
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 175..179
FT /evidence="ECO:0007829|PDB:6BS3"
FT STRAND 184..187
FT /evidence="ECO:0007829|PDB:6BS4"
FT HELIX 188..200
FT /evidence="ECO:0007829|PDB:6BS3"
FT STRAND 204..210
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 214..229
FT /evidence="ECO:0007829|PDB:6BS3"
FT STRAND 234..242
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 249..255
FT /evidence="ECO:0007829|PDB:6BS3"
FT TURN 256..258
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 262..271
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 278..302
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 303..305
FT /evidence="ECO:0007829|PDB:6BS3"
FT STRAND 312..316
FT /evidence="ECO:0007829|PDB:6BS3"
FT HELIX 324..336
FT /evidence="ECO:0007829|PDB:6BS3"
SQ SEQUENCE 340 AA; 35856 MW; 64E42BDD95A7635C CRC64;
MVATTSSGGS SVGWPSRLSG VRLHLVTGKG GTGKSTIAAA LALTLAAGGR KVLLVEVEGR
QGIAQLFDVP PLPYQELKIA TAERGGQVNA LAIDIEAAFL EYLDMFYNLG IAGRAMRRIG
AVEFATTIAP GLRDVLLTGK IKETVVRLDK NKLPVYDAIV VDAPPTGRIA RFLDVTKAVS
DLAKGGPVHA QSEGVVKLLH SNQTAIHLVT LLEALPVQET LEAIEELAQM ELPIGSVIVN
RNIPAHLEPQ DLAKAAEGEV DADSVRAGLL TAGVKLPDAD FAGLLTETIQ HATRITARAE
IAQQLDALQV PRLELPTVSD GVDLGSLYEL SESLAQQGVR
