CARL3_RAT
ID CARL3_RAT Reviewed; 1373 AA.
AC Q5XHY1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 18-MAR-2008, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Capping protein, Arp2/3 and myosin-I linker protein 3 {ECO:0000250|UniProtKB:Q8ND23};
DE AltName: Full=Capping protein regulator and myosin 1 linker protein 3;
DE AltName: Full=Leucine-rich repeat-containing protein 16B {ECO:0000312|RGD:1359120};
GN Name=Carmil3; Synonyms=Lrrc16b {ECO:0000312|RGD:1359120};
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brown Norway;
RX PubMed=15057822; DOI=10.1038/nature02426;
RA Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA Mockrin S., Collins F.S.;
RT "Genome sequence of the Brown Norway rat yields insights into mammalian
RT evolution.";
RL Nature 428:493-521(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 685-1373.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP TISSUE SPECIFICITY.
RX PubMed=21102520; DOI=10.1038/onc.2010.451;
RA Hsu C.C., Chiang C.W., Cheng H.C., Chang W.T., Chou C.Y., Tsai H.W.,
RA Lee C.T., Wu Z.H., Lee T.Y., Chao A., Chow N.H., Ho C.L.;
RT "Identifying LRRC16B as an oncofetal gene with transforming enhancing
RT capability using a combined bioinformatics and experimental approach.";
RL Oncogene 30:654-667(2011).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8ND23}. Cell
CC membrane {ECO:0000250|UniProtKB:Q8ND23}.
CC -!- TISSUE SPECIFICITY: Widely expressed, with much higher levels in fetal
CC tissues than in adult ones. Highly expressed in newborn brain.
CC {ECO:0000269|PubMed:21102520}.
CC -!- DOMAIN: The C-terminus is necessary for localization to the cell
CC membrane. {ECO:0000250|UniProtKB:Q8ND23}.
CC -!- SIMILARITY: Belongs to the CARMIL family. {ECO:0000305}.
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DR EMBL; AABR03095815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC083918; AAH83918.2; -; mRNA.
DR RefSeq; XP_008768907.1; XM_008770685.2.
DR AlphaFoldDB; Q5XHY1; -.
DR SMR; Q5XHY1; -.
DR STRING; 10116.ENSRNOP00000036263; -.
DR PaxDb; Q5XHY1; -.
DR PRIDE; Q5XHY1; -.
DR GeneID; 361041; -.
DR UCSC; RGD:1359120; rat.
DR CTD; 90668; -.
DR RGD; 1359120; Carmil3.
DR eggNOG; KOG4242; Eukaryota.
DR HOGENOM; CLU_003119_3_2_1; -.
DR InParanoid; Q5XHY1; -.
DR OrthoDB; 208951at2759; -.
DR PhylomeDB; Q5XHY1; -.
DR TreeFam; TF316381; -.
DR PRO; PR:Q5XHY1; -.
DR Proteomes; UP000002494; Unplaced.
DR Genevisible; Q5XHY1; RN.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0030027; C:lamellipodium; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:2000249; P:regulation of actin cytoskeleton reorganization; IBA:GO_Central.
DR GO; GO:0034315; P:regulation of Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR029766; CARMIL3.
DR InterPro; IPR031943; CARMIL_C.
DR InterPro; IPR041245; CARMIL_PH.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR24112:SF43; PTHR24112:SF43; 1.
DR Pfam; PF17888; Carm_PH; 1.
DR Pfam; PF16000; CARMIL_C; 1.
DR Pfam; PF13516; LRR_6; 2.
PE 2: Evidence at transcript level;
KW Cell membrane; Cytoplasm; Leucine-rich repeat; Membrane;
KW Reference proteome; Repeat.
FT CHAIN 1..1373
FT /note="Capping protein, Arp2/3 and myosin-I linker protein
FT 3"
FT /id="PRO_0000324610"
FT REPEAT 242..269
FT /note="LRR 1"
FT REPEAT 272..299
FT /note="LRR 2"
FT REPEAT 333..358
FT /note="LRR 3"
FT REPEAT 390..417
FT /note="LRR 4"
FT REPEAT 422..446
FT /note="LRR 5"
FT REPEAT 453..475
FT /note="LRR 6"
FT REPEAT 480..507
FT /note="LRR 7"
FT REPEAT 510..536
FT /note="LRR 8"
FT REPEAT 541..564
FT /note="LRR 9"
FT REPEAT 568..591
FT /note="LRR 10"
FT REGION 126..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 970..1373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 882..897
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 979..995
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1006..1020
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1074..1099
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1267..1281
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1341..1358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1373 AA; 149898 MW; 1BB21F9F601F0ADB CRC64;
MAKASVELTR ELQDSIRRCL SQGAVLQQHR VKLETKPKKF EDRVLALTSW RLHLFPLKVP
AKVESSFNVL EIRAFNTLSQ NQILVETERG VVSMRLPSAE SVDQVTRHVS SALSKVCPGP
GCLIRRGNAD TPEGPRDTSP NSETSTSTTH SVCGGFSETY AALCDYNGLH CREEVQWDVD
TIYHAEDNRE FNLLDFSHLE SRDLALMVAA LAYNQWFTKL YCKDLRLGSE VLEQVLHTLS
KSGSLEELVL DNAGLKTDFV QKLAGVFGEN GSCVLHALTL SHNPIEDKGF LSLSQQLLCF
PAGLTKLCLA KTAVSPRGLQ ALGQTFGANP AFASSLRYLD LSKNPGLLAT DEANALYSFL
AQPNALVHLD LSGTDCAVDL LLGALLHGCC SHLTYLNLAR NSCSHRKGRE APPAFKQFFS
SAYTLSHVNL SATRLPLEAL RALLQGLSLN SHLSDLHLDL SSCELRSAGA QALQEQLGAV
TCIGSLDLSD NGFDSDLLTL VPALGKNKSL KHLFLGKNFN VKAKTLEEIL HKLVQLIQEE
DCSLQSLSVA DSRLKLRTSI LINALGSNTC LAKVDLSGNG MEDIGAKMLS KALQINSSLR
TILWDRNNTS ALGFLDIARA LESNHTLRFM SFPVSDISQA YRSAPERTED VWQKIQWCLV
RNNHSQTCPQ EQAFRLQQGL VTSSAEQMLQ RLCGRVQEEV RALRLCPLEP VQDELLYARD
LIKDAKNSRA LFPSLCELGH VLANDGPVRQ RLESVASEVS KAVDKELQVI LESMVSLTQE
LCPVAMRVAE GHNKMLSNVA ERVTVPRNFI RGALLEQAGQ DIQNKLDEVK LSVVTYLTNS
IVDEILQELY HSHKSLARHL TQLRTLSDPP GGAGPGQDPS SRGRGRSHDH EETDDELGTN
IDTMAIKKQK RCRKIRPVSA FISGSPQDME SQLGSLGIPP GWFSGLGSSQ PTASGSWEGL
SELPTHGYKL RHQTQGRPRP PRTTPPGPGR PSVPVPGPRQ ENGMATRLDE GLEDFFSRRV
MDESSSYPRT LRTMRPGPSE PPLPALQKRR RRGLFHFRRP RSFKGDRGPG SPTAGLLLPP
PPPPPPTQES PPSPDPPSLG NNSSPCWSPE EESSLLPGFG GARGSSFCRK MGTERLEAGD
GAPAPGTAQP PRVHGVALPG LGRTKGWSFD GKREGTDPDQ EDSTQAWQKR RSSDDAGPGA
WKPPPPPQSS KPSFSAMRRA EATWHIAEES APNHSCQSPS PASQDGEEEK DGALFPERMV
PARNAKEPPI GPRPPKPVAV PRGRRAPQVP GGREEAESSS AAPGANKPWL RLGSQQDQEE
PEGQVPSDLG RRTAPLKPKR TRRAQSCDKL EPDRRRPPDP AGVCAGTSEP GTD
