ID   Y3716_MYCTU             Reviewed;         133 AA.
AC   P9WNR9; L0TF16; O69683; P0A654;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Nucleoid-associated protein Rv3716c {ECO:0000255|HAMAP-Rule:MF_00274};
GN   OrderedLocusNames=Rv3716c; ORFNames=MTV025.064c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=11681203;
RX   DOI=10.1002/1615-9861(200104)1:4<494::aid-prot494>3.0.co;2-4;
RA   Mattow J., Jungblut P.R., Mueller E.-C., Kaufmann S.H.E.;
RT   "Identification of acidic, low molecular mass proteins of Mycobacterium
RT   tuberculosis strain H37Rv by matrix-assisted laser desorption/ionization
RT   and electrospray ionization mass spectrometry.";
RL   Proteomics 1:494-507(2001).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Binds to DNA and alters its conformation. May be involved in
CC       regulation of gene expression, nucleoid organization and DNA
CC       protection. {ECO:0000255|HAMAP-Rule:MF_00274}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000255|HAMAP-Rule:MF_00274}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid {ECO:0000255|HAMAP-
CC       Rule:MF_00274}.
CC   -!- SIMILARITY: Belongs to the YbaB/EbfC family. {ECO:0000255|HAMAP-
CC       Rule:MF_00274}.
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DR   EMBL; AL123456; CCP46542.1; -; Genomic_DNA.
DR   PIR; E70795; E70795.
DR   RefSeq; NP_218233.1; NC_000962.3.
DR   RefSeq; WP_003420408.1; NZ_NVQJ01000009.1.
DR   PDB; 5YRX; X-ray; 1.90 A; A=1-133.
DR   PDBsum; 5YRX; -.
DR   AlphaFoldDB; P9WNR9; -.
DR   SMR; P9WNR9; -.
DR   STRING; 83332.Rv3716c; -.
DR   PaxDb; P9WNR9; -.
DR   DNASU; 885595; -.
DR   GeneID; 45427715; -.
DR   GeneID; 885595; -.
DR   KEGG; mtu:Rv3716c; -.
DR   TubercuList; Rv3716c; -.
DR   eggNOG; COG0718; Bacteria.
DR   OMA; MGNMMKQ; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0043590; C:bacterial nucleoid; IEA:UniProtKB-UniRule.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   Gene3D; 3.30.1310.10; -; 1.
DR   HAMAP; MF_00274; DNA_YbaB_EbfC; 1.
DR   InterPro; IPR036894; YbaB-like_sf.
DR   InterPro; IPR004401; YbaB/EbfC.
DR   PANTHER; PTHR33449; PTHR33449; 1.
DR   Pfam; PF02575; YbaB_DNA_bd; 1.
DR   PIRSF; PIRSF004555; UCP004555; 1.
DR   SUPFAM; SSF82607; SSF82607; 1.
DR   TIGRFAMs; TIGR00103; DNA_YbaB_EbfC; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; DNA-binding; Reference proteome.
FT   CHAIN           1..133
FT                   /note="Nucleoid-associated protein Rv3716c"
FT                   /id="PRO_0000170412"
FT   REGION          98..133
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..133
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           23..26
FT                   /evidence="ECO:0007829|PDB:5YRX"
FT   TURN            27..30
FT                   /evidence="ECO:0007829|PDB:5YRX"
FT   STRAND          32..37
FT                   /evidence="ECO:0007829|PDB:5YRX"
FT   TURN            38..41
FT                   /evidence="ECO:0007829|PDB:5YRX"
FT   STRAND          42..47
FT                   /evidence="ECO:0007829|PDB:5YRX"
FT   STRAND          52..57
FT                   /evidence="ECO:0007829|PDB:5YRX"
FT   HELIX           59..61
FT                   /evidence="ECO:0007829|PDB:5YRX"
FT   HELIX           67..89
FT                   /evidence="ECO:0007829|PDB:5YRX"
SQ   SEQUENCE   133 AA;  13357 MW;  9D689EE3170AE782 CRC64;
     MQPGGDMSAL LAQAQQMQQK LLEAQQQLAN SEVHGQAGGG LVKVVVKGSG EVIGVTIDPK
     VVDPDDIETL QDLIVGAMRD ASQQVTKMAQ ERLGALAGAM RPPAPPAAPP GAPGMPGMPG
     MPGAPGAPPV PGI