ID   Y377_CLOP1              Reviewed;         481 AA.
AC   Q0TU56; P30818;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Putative amino-acid transporter CPF_0377;
GN   OrderedLocusNames=CPF_0377;
OS   Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB
OS   6125 / NCTC 8237 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195103;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / S 107 /
RC   Type A;
RX   PubMed=16825665; DOI=10.1101/gr.5238106;
RA   Myers G.S.A., Rasko D.A., Cheung J.K., Ravel J., Seshadri R., DeBoy R.T.,
RA   Ren Q., Varga J., Awad M.M., Brinkac L.M., Daugherty S.C., Haft D.H.,
RA   Dodson R.J., Madupu R., Nelson W.C., Rosovitz M.J., Sullivan S.A.,
RA   Khouri H., Dimitrov G.I., Watkins K.L., Mulligan S., Benton J., Radune D.,
RA   Fisher D.J., Atkins H.S., Hiscox T., Jost B.H., Billington S.J.,
RA   Songer J.G., McClane B.A., Titball R.W., Rood J.I., Melville S.B.,
RA   Paulsen I.T.;
RT   "Skewed genomic variability in strains of the toxigenic bacterial pathogen,
RT   Clostridium perfringens.";
RL   Genome Res. 16:1031-1040(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-35.
RX   PubMed=2108713; DOI=10.1021/bi00453a016;
RA   van Poelje P.D., Snell E.E.;
RT   "Cloning, sequencing, expression, and site-directed mutagenesis of the gene
RT   from Clostridium perfringens encoding pyruvoyl-dependent histidine
RT   decarboxylase.";
RL   Biochemistry 29:132-139(1990).
CC   -!- FUNCTION: Could be an amino acid transporter.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC       family. {ECO:0000305}.
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DR   EMBL; CP000246; ABG83796.1; -; Genomic_DNA.
DR   EMBL; J02880; AAA83527.1; -; Genomic_DNA.
DR   PIR; B33770; B33770.
DR   RefSeq; WP_003455623.1; NC_008261.1.
DR   AlphaFoldDB; Q0TU56; -.
DR   SMR; Q0TU56; -.
DR   STRING; 195103.CPF_0377; -.
DR   EnsemblBacteria; ABG83796; ABG83796; CPF_0377.
DR   GeneID; 29572498; -.
DR   KEGG; cpf:CPF_0377; -.
DR   eggNOG; COG0531; Bacteria.
DR   HOGENOM; CLU_007946_1_2_9; -.
DR   OMA; YFWSSAY; -.
DR   OrthoDB; 527053at2; -.
DR   Proteomes; UP000001823; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004754; Amino_acid_antiprt.
DR   Pfam; PF13520; AA_permease_2; 1.
DR   TIGRFAMs; TIGR00905; 2A0302; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..481
FT                   /note="Putative amino-acid transporter CPF_0377"
FT                   /id="PRO_0000259457"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   481 AA;  52759 MW;  8C291010FDE2A91F CRC64;
     MNDNKKLGVI ALAGVVISAM LGGGVYNLPQ NMAQSASAGA ILISWIITGI GIWFIANTFR
     ILAAARPDAT TGIYTYGELG FGKFTGFLMA WGYWICNSFA NVGYAVLLMD SLNYFFPPYF
     KGGNNWLSIA CGSLVLWIIF FIVLAGVKQA SALNVIGTIG KLLPLAIFLL VLLFSFRFST
     FFTDFWGLKT VAKVHDTNLG GILPQVKSTM LVTLWVFTGI EGAVVVSGRA KSQKDVSKAT
     FLGFITCLLI YTLLSLLPLG VYSQGEISKM APPSTAAVLM DLIGNWGSVI MNLGVIIAIL
     SSWLIWTVML SELPFAAAQS GTFPKIFAKE NKNESPSFSL LASTIIMQII LILVHFAGNA
     WNMMLSITSV MALPCYLVST LYLFKITYKN ENYPTDIFAK RKYAMITAIL GSIYGVWLIY
     AAGINYMLIA IVIYALGIPV FIKARRETSP NEKEFTKVER YFAIVLIILA LIGLVYLFKF
     M