ID   Y377_MYCTO              Reviewed;         321 AA.
AC   P9WMF6; L0T6H5; O53712;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator MT0391;
GN   OrderedLocusNames=MT0391;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AE000516; AAK44613.1; -; Genomic_DNA.
DR   PIR; D70833; D70833.
DR   RefSeq; WP_003898421.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WMF6; -.
DR   SMR; P9WMF6; -.
DR   EnsemblBacteria; AAK44613; AAK44613; MT0391.
DR   KEGG; mtc:MT0391; -.
DR   PATRIC; fig|83331.31.peg.416; -.
DR   HOGENOM; CLU_076586_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Transcription; Transcription regulation.
FT   CHAIN           1..321
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   MT0391"
FT                   /id="PRO_0000427312"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   321 AA;  33637 MW;  06200F0F3D280C59 CRC64;
     MTPAQLRAYS AVVRLGSVRA AAAELGLSDA GVSMHVAALR KELDDPLFTR TGAGLAFTPG
     GLRLASRAVE ILGLQQQTAI EVTEAAHGRR LLRIAASSAF AEHAAPGLIE LFSSRADDLS
     VELSVHPTSR FRELICSRAV DIAIGPASES SIGSDGSIFL RPFLKYQIIT VVAPNSPLAA
     GIPMPALLRH QQWMLGPSAG SVDGEIATML RGLAIPESQQ RIFQSDAAAL EEVMRVGGAT
     LAIGFAVAKD LAAGRLVHVT GPGLDRAGEW CVATLAPSAR QPAVSELVGF ISTPRCIQAM
     IPGSGVGVTR FRPKVHVTLW S