ID   Y377_MYCTU              Reviewed;         321 AA.
AC   P9WMF7; L0T6H5; O53712;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=Uncharacterized HTH-type transcriptional regulator Rv0377;
GN   OrderedLocusNames=Rv0377; ORFNames=MTV036.12;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; AL123456; CCP43107.1; -; Genomic_DNA.
DR   PIR; D70833; D70833.
DR   RefSeq; NP_214891.1; NC_000962.3.
DR   RefSeq; WP_003898421.1; NZ_NVQJ01000002.1.
DR   AlphaFoldDB; P9WMF7; -.
DR   SMR; P9WMF7; -.
DR   STRING; 83332.Rv0377; -.
DR   PaxDb; P9WMF7; -.
DR   DNASU; 886452; -.
DR   GeneID; 886452; -.
DR   KEGG; mtu:Rv0377; -.
DR   TubercuList; Rv0377; -.
DR   eggNOG; COG0583; Bacteria.
DR   OMA; QIFQSHA; -.
DR   PhylomeDB; P9WMF7; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..321
FT                   /note="Uncharacterized HTH-type transcriptional regulator
FT                   Rv0377"
FT                   /id="PRO_0000105811"
FT   DOMAIN          1..58
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   321 AA;  33637 MW;  06200F0F3D280C59 CRC64;
     MTPAQLRAYS AVVRLGSVRA AAAELGLSDA GVSMHVAALR KELDDPLFTR TGAGLAFTPG
     GLRLASRAVE ILGLQQQTAI EVTEAAHGRR LLRIAASSAF AEHAAPGLIE LFSSRADDLS
     VELSVHPTSR FRELICSRAV DIAIGPASES SIGSDGSIFL RPFLKYQIIT VVAPNSPLAA
     GIPMPALLRH QQWMLGPSAG SVDGEIATML RGLAIPESQQ RIFQSDAAAL EEVMRVGGAT
     LAIGFAVAKD LAAGRLVHVT GPGLDRAGEW CVATLAPSAR QPAVSELVGF ISTPRCIQAM
     IPGSGVGVTR FRPKVHVTLW S