ID   Y378_METTH              Reviewed;         334 AA.
AC   O26478;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=UPF0104 membrane protein MTH_378;
GN   OrderedLocusNames=MTH_378;
OS   Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS   10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC   Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC   Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX   NCBI_TaxID=187420;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX   PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA   Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA   Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA   Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA   Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA   Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA   Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA   Reeve J.N.;
RT   "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT   functional analysis and comparative genomics.";
RL   J. Bacteriol. 179:7135-7155(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the UPF0104 family. {ECO:0000305}.
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DR   EMBL; AE000666; AAB84884.1; -; Genomic_DNA.
DR   PIR; H69148; H69148.
DR   RefSeq; WP_010876017.1; NC_000916.1.
DR   AlphaFoldDB; O26478; -.
DR   STRING; 187420.MTH_378; -.
DR   EnsemblBacteria; AAB84884; AAB84884; MTH_378.
DR   GeneID; 1470339; -.
DR   KEGG; mth:MTH_378; -.
DR   PATRIC; fig|187420.15.peg.347; -.
DR   HOGENOM; CLU_048072_1_1_2; -.
DR   OMA; FINWRED; -.
DR   Proteomes; UP000005223; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR022791; L-PG_synthase/AglD.
DR   Pfam; PF03706; LPG_synthase_TM; 1.
DR   TIGRFAMs; TIGR00374; TIGR00374; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..334
FT                   /note="UPF0104 membrane protein MTH_378"
FT                   /id="PRO_0000138106"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        120..140
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        142..162
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        218..238
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   334 AA;  36959 MW;  46D280EC683CB611 CRC64;
     MDSMKRFYFF ALSILLILAL IIWMGPSRII RAVYMADWMI IAIALLIHMG VLAVRGLRWG
     FIIGQPWRMR VNFMVKTIGL FAGNLSPMRS AGEVMNALAG KKLNGIELSE GLSAGLTERF
     FDLGIGGGLL LLAAVMVPVI RVIALFGAIL SVLITYLIYL VNWREEKGLR IYQRIHSIIE
     RLPVSEETLE NLYERLTSGI KGMIGYTRSY SNFTSLGVIF ILSLLSWLME CLRLYLVFMA
     FGVETSFSAV IIIFLLANLV GILSALPGGM GSMEVSMAGL FVVFGVPGFL AGSIALVDRI
     ISFWMVTALG AIFSSCYAGE IFDEVRSYIL DIRA