ID   Y378_MYCLE              Reviewed;         359 AA.
AC   Q49857;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 121.
DE   RecName: Full=Uncharacterized protein ML0378;
DE   Flags: Precursor;
GN   OrderedLocusNames=ML0378; ORFNames=B229_C1_170;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
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DR   EMBL; U00020; AAA17291.1; -; Genomic_DNA.
DR   EMBL; AL583918; CAC29886.1; -; Genomic_DNA.
DR   PIR; S72977; S72977.
DR   RefSeq; NP_301370.1; NC_002677.1.
DR   RefSeq; WP_010907694.1; NC_002677.1.
DR   AlphaFoldDB; Q49857; -.
DR   SMR; Q49857; -.
DR   STRING; 272631.ML0378; -.
DR   EnsemblBacteria; CAC29886; CAC29886; CAC29886.
DR   KEGG; mle:ML0378; -.
DR   PATRIC; fig|272631.5.peg.640; -.
DR   Leproma; ML0378; -.
DR   eggNOG; COG0456; Bacteria.
DR   eggNOG; COG1214; Bacteria.
DR   HOGENOM; CLU_771216_0_0_11; -.
DR   OMA; VQAFPWT; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IEA:InterPro.
DR   GO; GO:0006474; P:N-terminal protein amino acid acetylation; IEA:InterPro.
DR   GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; IEA:InterPro.
DR   InterPro; IPR006464; AcTrfase_RimI/Ard1.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR000905; Gcp-like_dom.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR022496; T6A_TsaB.
DR   PANTHER; PTHR11735; PTHR11735; 1.
DR   PANTHER; PTHR11735:SF11; PTHR11735:SF11; 1.
DR   Pfam; PF00583; Acetyltransf_1; 1.
DR   Pfam; PF00814; TsaD; 1.
DR   SUPFAM; SSF53067; SSF53067; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   TIGRFAMs; TIGR01575; rimI; 1.
DR   TIGRFAMs; TIGR03725; T6A_YeaZ; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Reference proteome; Signal.
FT   SIGNAL          1..15
FT                   /evidence="ECO:0000255"
FT   CHAIN           16..359
FT                   /note="Uncharacterized protein ML0378"
FT                   /id="PRO_0000014155"
FT   DOMAIN          212..359
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00532"
SQ   SEQUENCE   359 AA;  38018 MW;  0B9A13C6E15C8706 CRC64;
     MSIVLAIDTA TAAVTAGIVA FDGHDCFTLA ERVTVDAKAH VERLTPNVLV ALADAELAMC
     ELDAVVVGCG PGPFTGLRVG MATAAAYGHA LGIPVHGVCS LDAIGVRTTG DTLVVTDARR
     HEVYWARYRD GVRIAGPAVG SPTDVDPGTA LTVAGSPEHA ALFGLPLCEP IYPTPAGLVA
     AVPDWSVSPI PLVALYLRRP DAKPITADNE PIVIGTLTPA DVDRCAQLES QFFDGDNPWP
     AAAFDRELAN SYNCYVGART ADTLVGYAGI TRLGHTPPFE YEVHTIAVDP AYRGRGVGRR
     LLGELLDFAG SGAIYLEVRT DNETAIALYR SVGFERIGLR PRYYPASGAD AYLMRREAQ