ID   Y379_MYCSK              Reviewed;         300 AA.
AC   A1U9T8;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase Mkms_0379;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Mkms_0379;
OS   Mycobacterium sp. (strain KMS).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; unclassified Mycobacterium.
OX   NCBI_TaxID=189918;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KMS;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Kiss H., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Miller C.D.,
RA   Richardson P.;
RT   "Complete sequence of chromosome of Mycobacterium sp. KMS.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; CP000518; ABL89596.1; -; Genomic_DNA.
DR   RefSeq; WP_011557796.1; NC_008705.1.
DR   AlphaFoldDB; A1U9T8; -.
DR   SMR; A1U9T8; -.
DR   STRING; 189918.Mkms_0379; -.
DR   EnsemblBacteria; ABL89596; ABL89596; Mkms_0379.
DR   KEGG; mkm:Mkms_0379; -.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; NEQCAPA; -.
DR   OrthoDB; 847145at2; -.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..300
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase Mkms_0379"
FT                   /id="PRO_0000361213"
FT   BINDING         128
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         157..158
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   300 AA;  32913 MW;  8CF763FAEF9666DE CRC64;
     MRHDNDSWDI TTSVGSTALF VAASRALEAR KPDPLAVDPY AEVFCRAAGG DWAGLFDAGA
     DPKPDHVLFS EFGEQFVNFQ GARTRYFDAY FAAASDAGVR QVVLLAAGLD SRAYRLPWPD
     GTVVYELDQP RVLEFKREVL AERGEQPVAQ RREVAVDLRD DWCAALTAAG FDPARPSAWL
     AEGLLMYLPA TAQEALFSGI DALSAPRSWA AVEESVPMPA EVFAYKREEE RAAGEEGTFF
     TLVYNERHAP AERWFGERGW AAEPTSLADY LTRVGRPAPV DDPEFGAMIS AIRLVTATKG