Y3800_DICDI
ID Y3800_DICDI Reviewed; 806 AA.
AC Q54BA2;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Ankyrin repeat, bromo and BTB domain-containing protein DDB_G0293800;
GN ORFNames=DDB_G0293800;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=16596165; DOI=10.1371/journal.pgen.0020038;
RA Goldberg J.M., Manning G., Liu A., Fey P., Pilcher K.E., Xu Y., Smith J.L.;
RT "The dictyostelium kinome -- analysis of the protein kinases from a simple
RT model organism.";
RL PLoS Genet. 2:E38-E38(2006).
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DR EMBL; AAFI02000220; EAL60533.1; -; Genomic_DNA.
DR RefSeq; XP_628948.1; XM_628946.1.
DR AlphaFoldDB; Q54BA2; -.
DR SMR; Q54BA2; -.
DR STRING; 44689.DDB0220694; -.
DR PaxDb; Q54BA2; -.
DR EnsemblProtists; EAL60533; EAL60533; DDB_G0293800.
DR GeneID; 8629425; -.
DR KEGG; ddi:DDB_G0293800; -.
DR dictyBase; DDB_G0293800; -.
DR eggNOG; KOG1474; Eukaryota.
DR eggNOG; KOG4177; Eukaryota.
DR HOGENOM; CLU_349656_0_0_1; -.
DR InParanoid; Q54BA2; -.
DR OMA; EREESIH; -.
DR PRO; PR:Q54BA2; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070577; F:lysine-acetylated histone binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.20.1270.220; -; 1.
DR Gene3D; 1.20.920.10; -; 1.
DR Gene3D; 1.25.40.20; -; 2.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR027353; NET_dom.
DR InterPro; IPR038336; NET_sf.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF17035; BET; 1.
DR Pfam; PF00439; Bromodomain; 1.
DR Pfam; PF00651; BTB; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00248; ANK; 4.
DR SMART; SM00297; BROMO; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF47370; SSF47370; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00633; BROMODOMAIN_1; 1.
DR PROSITE; PS50014; BROMODOMAIN_2; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS51525; NET; 1.
PE 4: Predicted;
KW ANK repeat; Bromodomain; Reference proteome; Repeat.
FT CHAIN 1..806
FT /note="Ankyrin repeat, bromo and BTB domain-containing
FT protein DDB_G0293800"
FT /id="PRO_0000367481"
FT REPEAT 1..30
FT /note="ANK 1"
FT REPEAT 34..63
FT /note="ANK 2"
FT REPEAT 67..96
FT /note="ANK 3"
FT REPEAT 100..130
FT /note="ANK 4"
FT REPEAT 134..163
FT /note="ANK 5"
FT DOMAIN 239..307
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 533..605
FT /note="Bromo"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00035"
FT DOMAIN 727..806
FT /note="NET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00857"
FT REGION 210..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 423..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 621..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..642
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..657
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 658..674
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 675..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 88947 MW; 7C28297D26FB5F1F CRC64;
MSNKTLPYCC EHGLKDEVIA LLAKGEDVNQ KDGSNRYPLH YAAIGGYIEI VAMLLERGAL
VNCSTPRGAT PLHYASRGGR IECIQLLIDN KADVNCRDGA GSTPLHTALQ CNETKCAIAL
IETFGADVNL KTAEGSTALH LASARGLVPV IVALLENGAR ADVRDSKENS PFQSLPINLT
ENEKKEKIEN SISQDISKLF NINKNREFSG VGKKEDDDNN MKIDKQESEQ QSTSDKLYSD
ITFLIENQKV YAHKCILQAR CPNFMSSINN KIEQQQSQKP IEIKDYSFKL FLSFIEWIYT
GSIEKFESTS KSIDLSFQFS ILLMGEKFDC KGLVSYCREF IKESIGDSNV GSIWSIIKKL
PTSTRSNLGN LVRDCLITMV RSWNIFTMTK TFSTDINKSD IIEIIKSLAP FITETPISEI
KQTRTANANA SNSNQSKTPA KRTSTTNTNN NIPQQNITSS NNTPQQNTSS SSSSSTTSST
PSKSSSSTPS KSTSTSSSSS SSSSSSSSSS SNYSDSMNEK NLTFCKGLIN GMFKKKTSLA
FQRPVDPLAE GIPDYFDVIK HPMDLGTIKG KLDNNGYSTI KDFAADVRLM FENALTYNAD
SSPVWKHAKT LLNAFDQKFL QNFPNEKPPT YKPPPPTPTP IPTQQQQQQS TSSTSTPTSE
KKRKHDEHVK VKEDTNSAQP TSSSSNHTNG ENASSSSSSS SSKQSNNNNN NNNNNNSNST
TNSSSSSSST TTTQKKYSDE ERRSLMERIN ELAPDDVQEV LNIIDPNAIK QADESLEIDM
YQIDDKNLSQ VESFINECFK KQKQDE
