ID   Y3805_MYCTA             Reviewed;         314 AA.
AC   A5U994;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase MRA_3805;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=MRA_3805;
OS   Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=419947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25177 / H37Ra;
RX   PubMed=18584054; DOI=10.1371/journal.pone.0002375;
RA   Zheng H., Lu L., Wang B., Pu S., Zhang X., Zhu G., Shi W., Zhang L.,
RA   Wang H., Wang S., Zhao G., Zhang Y.;
RT   "Genetic basis of virulence attenuation revealed by comparative genomic
RT   analysis of Mycobacterium tuberculosis strain H37Ra versus H37Rv.";
RL   PLoS ONE 3:E2375-E2375(2008).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; CP000611; ABQ75594.1; -; Genomic_DNA.
DR   RefSeq; WP_003420557.1; NZ_CP016972.1.
DR   AlphaFoldDB; A5U994; -.
DR   SMR; A5U994; -.
DR   STRING; 419947.MRA_3805; -.
DR   EnsemblBacteria; ABQ75594; ABQ75594; MRA_3805.
DR   KEGG; mra:MRA_3805; -.
DR   eggNOG; COG3315; Bacteria.
DR   HOGENOM; CLU_056160_2_1_11; -.
DR   OMA; DSMPPTL; -.
DR   OrthoDB; 847145at2; -.
DR   Proteomes; UP000001988; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   3: Inferred from homology;
KW   Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT   CHAIN           1..314
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase MRA_3805"
FT                   /id="PRO_0000361228"
FT   BINDING         132
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         161..162
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   314 AA;  34755 MW;  BACD884305460F6E CRC64;
     MPRTDNDSWA ITESVGATAL GVAAARAAET ESDNPLINDP FARIFVDAAG DGIWSMYTNR
     TLLAGATDLD PDLRAPIQQM IDFMAARTAF FDEYFLATAD AGVRQVVILA SGLDSRAWRL
     PWPDGTVVYE LDQPKVLEFK SATLRQHGAQ PASQLVNVPI DLRQDWPKAL QKAGFDPSKP
     CAWLAEGLVR YLPARAQDLL FERIDALSRP GSWLASNVPG AGFLDPERMR RQRADMRRMR
     AAAAKLVETE ISDVDDLWYA EQRTAVAEWL RERGWDVSTA TLPELLARYG RSIPHSGEDS
     IPPNLFVSAQ RATS