Y380_HAEIN
ID Y380_HAEIN Reviewed; 241 AA.
AC P44676; Q9RP31;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2002, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Uncharacterized tRNA/rRNA methyltransferase HI_0380 {ECO:0000305};
DE EC=2.1.1.-;
GN OrderedLocusNames=HI_0380;
OS Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=71421;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX PubMed=7542800; DOI=10.1126/science.7542800;
RA Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT Rd.";
RL Science 269:496-512(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RA Bonander N., Eisenstein E.;
RL Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC superfamily. RNA methyltransferase TrmH family. {ECO:0000305}.
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DR EMBL; L42023; AAC22038.1; -; Genomic_DNA.
DR EMBL; AF174385; AAD54289.1; -; Genomic_DNA.
DR PIR; G64150; G64150.
DR RefSeq; NP_438541.1; NC_000907.1.
DR PDB; 3ILK; X-ray; 2.01 A; A/B=1-241.
DR PDBsum; 3ILK; -.
DR AlphaFoldDB; P44676; -.
DR SMR; P44676; -.
DR STRING; 71421.HI_0380; -.
DR DNASU; 949482; -.
DR EnsemblBacteria; AAC22038; AAC22038; HI_0380.
DR KEGG; hin:HI_0380; -.
DR PATRIC; fig|71421.8.peg.398; -.
DR eggNOG; COG0565; Bacteria.
DR HOGENOM; CLU_056931_3_0_6; -.
DR PhylomeDB; P44676; -.
DR BioCyc; HINF71421:G1GJ1-393-MON; -.
DR EvolutionaryTrace; P44676; -.
DR Proteomes; UP000000579; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0052666; F:tRNA (cytosine-2'-O-)-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0052665; F:tRNA (uracil-2'-O-)-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0002128; P:tRNA nucleoside ribose methylation; IBA:GO_Central.
DR Gene3D; 3.40.1280.10; -; 1.
DR InterPro; IPR029028; Alpha/beta_knot_MTases.
DR InterPro; IPR004384; RNA_MeTrfase_TrmJ/LasT.
DR InterPro; IPR001537; SpoU_MeTrfase.
DR InterPro; IPR029026; tRNA_m1G_MTases_N.
DR PANTHER; PTHR42786; PTHR42786; 1.
DR Pfam; PF00588; SpoU_methylase; 1.
DR PIRSF; PIRSF004808; LasT; 1.
DR SUPFAM; SSF75217; SSF75217; 1.
DR TIGRFAMs; TIGR00050; rRNA_methyl_1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Methyltransferase; Reference proteome;
KW S-adenosyl-L-methionine; Transferase.
FT CHAIN 1..241
FT /note="Uncharacterized tRNA/rRNA methyltransferase HI_0380"
FT /id="PRO_0000159830"
FT BINDING 78..80
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250|UniProtKB:P0AE01"
FT BINDING 111
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250|UniProtKB:P0AE01"
FT BINDING 131
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250|UniProtKB:P0AE01"
FT BINDING 138..140
FT /ligand="S-adenosyl-L-methionine"
FT /ligand_id="ChEBI:CHEBI:59789"
FT /evidence="ECO:0000250|UniProtKB:P0AE01"
FT CONFLICT 73
FT /note="S -> P (in Ref. 1; AAC22038)"
FT /evidence="ECO:0000305"
FT STRAND 5..11
FT /evidence="ECO:0007829|PDB:3ILK"
FT HELIX 15..27
FT /evidence="ECO:0007829|PDB:3ILK"
FT STRAND 32..37
FT /evidence="ECO:0007829|PDB:3ILK"
FT HELIX 43..47
FT /evidence="ECO:0007829|PDB:3ILK"
FT TURN 48..51
FT /evidence="ECO:0007829|PDB:3ILK"
FT HELIX 53..58
FT /evidence="ECO:0007829|PDB:3ILK"
FT STRAND 60..64
FT /evidence="ECO:0007829|PDB:3ILK"
FT HELIX 65..68
FT /evidence="ECO:0007829|PDB:3ILK"
FT TURN 69..71
FT /evidence="ECO:0007829|PDB:3ILK"
FT STRAND 73..78
FT /evidence="ECO:0007829|PDB:3ILK"
FT HELIX 83..85
FT /evidence="ECO:0007829|PDB:3ILK"
FT TURN 86..88
FT /evidence="ECO:0007829|PDB:3ILK"
FT HELIX 92..101
FT /evidence="ECO:0007829|PDB:3ILK"
FT STRAND 106..110
FT /evidence="ECO:0007829|PDB:3ILK"
FT TURN 113..115
FT /evidence="ECO:0007829|PDB:3ILK"
FT HELIX 119..123
FT /evidence="ECO:0007829|PDB:3ILK"
FT STRAND 126..129
FT /evidence="ECO:0007829|PDB:3ILK"
FT HELIX 142..166
FT /evidence="ECO:0007829|PDB:3ILK"
FT HELIX 177..193
FT /evidence="ECO:0007829|PDB:3ILK"
FT HELIX 201..213
FT /evidence="ECO:0007829|PDB:3ILK"
FT HELIX 217..237
FT /evidence="ECO:0007829|PDB:3ILK"
SQ SEQUENCE 241 AA; 27241 MW; 82F6A9E5A17EC637 CRC64;
MLENIRIVLI ETSHSGNIGS AARAMKTMGL TQLCLVSPKS VDEQSYALSA GAENIVKNAR
VVDSFDEAVD DCSLVIGTSA RLRHLQNTLI EPRECAEKVV AYKGKIAIVF GRERIGLTNE
ELLKCHYHLN IPANPDYSSL NLAMAVQLVS YELRMAFLVQ NNKKNSLSLI EKNYPTTDQL
AYFFDYTERI YQSLGFIQNQ GVMRKLKRLY YRAKLEKNEL NILNGMLSAV EKRIDLTKED
N
