ID   Y3818_MYCTU             Reviewed;         516 AA.
AC   P9WH21; L0TFC4; O07805; Q7D4T6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Putative Rieske 2Fe-2S iron-sulfur protein Rv3818;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=Rv3818;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION AS A DRUG TARGET [LARGE SCALE ANALYSIS].
RX   PubMed=19099550; DOI=10.1186/1752-0509-2-109;
RA   Raman K., Yeturu K., Chandra N.;
RT   "targetTB: a target identification pipeline for Mycobacterium tuberculosis
RT   through an interactome, reactome and genome-scale structural analysis.";
RL   BMC Syst. Biol. 2:109-109(2008).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- COFACTOR:
CC       Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00628};
CC       Note=Binds 1 [2Fe-2S] cluster per subunit. {ECO:0000255|PROSITE-
CC       ProRule:PRU00628};
CC   -!- MISCELLANEOUS: Was identified as a high-confidence drug target.
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DR   EMBL; AL123456; CCP46647.1; -; Genomic_DNA.
DR   PIR; F70521; F70521.
DR   RefSeq; NP_218335.1; NC_000962.3.
DR   RefSeq; WP_003420837.1; NZ_NVQJ01000022.1.
DR   AlphaFoldDB; P9WH21; -.
DR   SMR; P9WH21; -.
DR   STRING; 83332.Rv3818; -.
DR   PaxDb; P9WH21; -.
DR   DNASU; 886153; -.
DR   GeneID; 886153; -.
DR   KEGG; mtu:Rv3818; -.
DR   TubercuList; Rv3818; -.
DR   eggNOG; COG2146; Bacteria.
DR   eggNOG; COG2220; Bacteria.
DR   OMA; DGWEIQR; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProt.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:UniProt.
DR   Gene3D; 2.102.10.10; -; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR017941; Rieske_2Fe-2S.
DR   InterPro; IPR036922; Rieske_2Fe-2S_sf.
DR   Pfam; PF00355; Rieske; 1.
DR   SUPFAM; SSF50022; SSF50022; 1.
DR   SUPFAM; SSF56281; SSF56281; 1.
DR   PROSITE; PS51296; RIESKE; 1.
PE   1: Evidence at protein level;
KW   2Fe-2S; Iron; Iron-sulfur; Metal-binding; Oxidoreductase;
KW   Reference proteome.
FT   CHAIN           1..516
FT                   /note="Putative Rieske 2Fe-2S iron-sulfur protein Rv3818"
FT                   /id="PRO_0000396106"
FT   DOMAIN          429..516
FT                   /note="Rieske"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT   BINDING         469
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT   BINDING         471
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT   BINDING         489
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
FT   BINDING         492
FT                   /ligand="[2Fe-2S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:190135"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00628"
SQ   SEQUENCE   516 AA;  57647 MW;  7C1C9E0C5E0B9BA5 CRC64;
     MQVTSVGHAG FLIQTQAGSI LCDPWVNPAY FASWFPFPDN SGLDWGALGE CDYLYVSHLH
     KDHFDAENLR AHVNKDAVVL LPDFPVPDLR NELQKLGFHR FFETTDSVKH RLRGPNGDLD
     VMIIALRAPA DGPIGDSALV VADGETTAFN MNDARPVDLD VLASEFGHID VHMLQYSGAI
     WYPMVYDMPA RAKDAFGAQK RQRQMDRARQ YIAQVGATWV VPSAGPPCFL APELRHLNDD
     GSDPANIFPD QMVFLDQMRA HGQDGGLLMI PGSTADFTGT TLNSLRHPLP AEQVEAIFTT
     DKAAYIADYA DRMAPVLAAQ KAGWAAAAGE PLLQPLRTLF EPIMLQSNEI CDGIGYPVEL
     AIGPETIVLD FPKRAVREPI PDERFRYGFA IAPELVRTVL RDNEPDWVNT IFLSTRFRAW
     RVGGYNEYLY TFFKCLTDER IAYADGWFAE AHDDSSSITL NGWEIQRRCP HLKADLSKFG
     VVEGNTLTCN LHGWQWRLDD GRCLTARGHQ LRSSRP