ID   Y381_BORBU              Reviewed;         474 AA.
AC   P94250; O50167;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Uncharacterized protein BB_0381;
GN   OrderedLocusNames=BB_0381;
OS   Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS   (Borrelia burgdorferi).
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=224326;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 53899 / 297;
RX   PubMed=8978084; DOI=10.1111/j.1574-6968.1996.tb08594.x;
RA   Aron L., Toth C., Godfrey H.P., Cabello F.C.;
RT   "Identification and mapping of a chromosomal gene cluster of Borrelia
RT   burgdorferi containing genes expressed in vivo.";
RL   FEMS Microbiol. Lett. 145:309-314(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA   Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA   Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA   van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA   Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA   Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA   Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL   Nature 390:580-586(1997).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; U49938; AAC44714.1; -; Genomic_DNA.
DR   EMBL; AE000783; AAC66759.1; ALT_TERM; Genomic_DNA.
DR   PIR; D70147; D70147.
DR   RefSeq; NP_212515.1; NC_001318.1.
DR   AlphaFoldDB; P94250; -.
DR   SMR; P94250; -.
DR   STRING; 224326.BB_0381; -.
DR   CAZy; GH63; Glycoside Hydrolase Family 63.
DR   PRIDE; P94250; -.
DR   EnsemblBacteria; AAC66759; AAC66759; BB_0381.
DR   KEGG; bbu:BB_0381; -.
DR   PATRIC; fig|224326.49.peg.776; -.
DR   HOGENOM; CLU_025779_0_0_12; -.
DR   OMA; INSLMWD; -.
DR   Proteomes; UP000001807; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004555; F:alpha,alpha-trehalase activity; IEA:InterPro.
DR   GO; GO:0005991; P:trehalose metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR001661; Glyco_hydro_37.
DR   PANTHER; PTHR23403; PTHR23403; 1.
DR   Pfam; PF01204; Trehalase; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
PE   4: Predicted;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..474
FT                   /note="Uncharacterized protein BB_0381"
FT                   /id="PRO_0000174399"
FT   TRANSMEM        374..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        33
FT                   /note="L -> F (in Ref. 1; AAC44714)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        40
FT                   /note="G -> T (in Ref. 1; AAC44714)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        107
FT                   /note="E -> D (in Ref. 1; AAC44714)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        365
FT                   /note="S -> A (in Ref. 1; AAC44714)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   474 AA;  55673 MW;  95C37254EDB84929 CRC64;
     MNKKMFPKIY YYDQDFIDIY NKSLSWIQDK VILQKVADRG KKDKNYYSEN CDYIDQMQAC
     MSSFFLVYSN GEYSSTSAID KFYQLQEESG AIRARYDNNN AIIDLDENEE NIGFPIFAWA
     EYNLYHKTGN KKRISEVLPI LDKYYKWIES KFLKENGLYS IDVNKIFYKN SPRVDAYYPI
     DFNSLQVHNA YCISKLADIL NDKNLSLEYK KRFFSLKVKI NSLMWSEKDG FYYDLDVNEN
     ILEIKTIVGF FPMLSEIPSE DRIERMIFYL KSTNHFGTPN PFPTLSVSEP GFSEDGNGYY
     GSVYTYMNFF VIKGLEYCGR ANIAREFTIR HLYYILDTLM PFNKIKGHIW EAYRPMQEGP
     AYFDSNKKTY TEKGLICYLA LFSISLMIEN IIGLTISLPD KTVYWNIPTL EIMGIESLSL
     KKNQTTIICN KGKRGWEIKM ESEKLYYFTI NILNKKEKTL PIPSGRCSML LDKL