ID   Y381_TREPA              Reviewed;         238 AA.
AC   O83396;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Uncharacterized protein TP_0381;
GN   OrderedLocusNames=TP_0381;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
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DR   EMBL; AE000520; AAC65382.1; -; Genomic_DNA.
DR   PIR; G71330; G71330.
DR   RefSeq; WP_010881829.1; NC_021490.2.
DR   AlphaFoldDB; O83396; -.
DR   IntAct; O83396; 1.
DR   STRING; 243276.TPANIC_0381; -.
DR   EnsemblBacteria; AAC65382; AAC65382; TP_0381.
DR   GeneID; 57878908; -.
DR   KEGG; tpa:TP_0381; -.
DR   eggNOG; COG5522; Bacteria.
DR   HOGENOM; CLU_088526_2_0_12; -.
DR   OMA; KEINAMF; -.
DR   OrthoDB; 1208418at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR011737; CHP02206_TP0381.
DR   Pfam; PF09529; Intg_mem_TP0381; 1.
DR   TIGRFAMs; TIGR02206; intg_mem_TP0381; 1.
PE   4: Predicted;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..238
FT                   /note="Uncharacterized protein TP_0381"
FT                   /id="PRO_0000202246"
FT   TRANSMEM        15..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        79..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        128..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        203..225
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   238 AA;  27120 MW;  2158C2FAA47D693D CRC64;
     MLGAELADTG LFVRFGALHF AIASVAVLLS ALFVLLPFAL PRLLAHKNLA RAGVAILFLR
     LGLMLCGTLL DGRSWRNELP FHLCPAALIS GSLYFITRRP IFFNLLYFWH FGSFVAVLYP
     DLTRAHTILY AYLFMLTHCL EPAMVVFSLL HLRERISKRG LQCAVLGFLL LAANALFWNR
     RLGANYLFIS KYPLEILRVI RPFFVYQLLF VSALCLLMLV LYLPFRPSQH GRNQLFVI