Y3835_MYCTU
ID Y3835_MYCTU Reviewed; 449 AA.
AC P9WKW5; L0TDX7; P96243; Q7D4S2;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 03-AUG-2022, entry version 32.
DE RecName: Full=Uncharacterized membrane protein Rv3835;
GN OrderedLocusNames=Rv3835;
OS Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83332;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=9634230; DOI=10.1038/31159;
RA Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA Barrell B.G.;
RT "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT genome sequence.";
RL Nature 393:537-544(1998).
RN [2]
RP INDUCTION BY STARVATION.
RX PubMed=11929527; DOI=10.1046/j.1365-2958.2002.02779.x;
RA Betts J.C., Lukey P.T., Robb L.C., McAdam R.A., Duncan K.;
RT "Evaluation of a nutrient starvation model of Mycobacterium tuberculosis
RT persistence by gene and protein expression profiling.";
RL Mol. Microbiol. 43:717-731(2002).
RN [3]
RP INDUCTION BY FTSZ INHIBITORS, AND FUNCTION.
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=16735741; DOI=10.1099/mic.0.28762-0;
RA Slayden R.A., Knudson D.L., Belisle J.T.;
RT "Identification of cell cycle regulators in Mycobacterium tuberculosis by
RT inhibition of septum formation and global transcriptional analysis.";
RL Microbiology 152:1789-1797(2006).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC STRAIN=ATCC 27294 / TMC 102 / H37Rv;
RX PubMed=17443846; DOI=10.1002/pmic.200600853;
RA Malen H., Berven F.S., Fladmark K.E., Wiker H.G.;
RT "Comprehensive analysis of exported proteins from Mycobacterium
RT tuberculosis H37Rv.";
RL Proteomics 7:1702-1718(2007).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 25618 / H37Rv;
RX PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT mass spectrometry.";
RL Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC -!- FUNCTION: May play a role in septum formation.
CC {ECO:0000269|PubMed:16735741}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:17443846}.
CC -!- INDUCTION: Down-regulated upon starvation. Induced by albendazole and
CC thiabendazole, which inhibit the GTPase activity of FtsZ and probably
CC septum formation. {ECO:0000269|PubMed:11929527,
CC ECO:0000269|PubMed:16735741}.
CC -!- MISCELLANEOUS: Has been detected in culture filtrate but no signal
CC sequence is predicted by bioinformatic programs.
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DR EMBL; AL123456; CCP46664.1; -; Genomic_DNA.
DR PIR; H70652; H70652.
DR RefSeq; NP_218352.1; NC_000962.3.
DR RefSeq; WP_003420892.1; NZ_NVQJ01000022.1.
DR AlphaFoldDB; P9WKW5; -.
DR STRING; 83332.Rv3835; -.
DR PaxDb; P9WKW5; -.
DR DNASU; 886168; -.
DR GeneID; 886168; -.
DR KEGG; mtu:Rv3835; -.
DR PATRIC; fig|83332.111.peg.4262; -.
DR TubercuList; Rv3835; -.
DR eggNOG; ENOG5030VN0; Bacteria.
DR OMA; PIKLRTT; -.
DR Proteomes; UP000001584; Chromosome.
DR GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009274; C:peptidoglycan-based cell wall; HDA:MTBBASE.
DR GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR InterPro; IPR026004; Septum_form.
DR Pfam; PF13845; Septum_form; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Secreted; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..449
FT /note="Uncharacterized membrane protein Rv3835"
FT /id="PRO_0000390678"
FT TRANSMEM 45..65
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..26
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..385
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 416..449
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 449 AA; 47043 MW; FD4DB3F778DC41AB CRC64;
MLDAPEQDPV DPGDPASPPH GEAEQPLPGP RWPRALRASA TRRALLLTAL GGLLIAGLVT
AIPAVGRAPE RLAGYIASNP VPSTGAKINA SFNRVASGDC LMWPDGTPES AAIVSCADEH
RFEVAESIDM RTFPGMEYGQ NAAPPSPARI QQISEEQCEA AVRRYLGTKF DPNSKFTISM
LWPGDRAWRQ AGERRMLCGL QSPGPNNQQL AFKGKVADID QSKVWPAGTC LGIDATTNQP
IDVPVDCAAP HAMEVSGTVN LAERFPDALP SEPEQDGFIK DACTRMTDAY LAPLKLRTTT
LTLIYPTLTL PSWSAGSRVV ACSIGATLGN GGWATLVNSA KGALLINGQP PVPPPDIPEE
RLNLPPIPLQ LPTPRPAPPA QQLPSTPPGT QHLPAQQPVV TPTRPPESHA PASAAPAETQ
PPPPDAGAPP ATQSPEATPP GPAEPAPAG
