ID   Y3857_ARATH             Reviewed;         617 AA.
AC   Q9C9Z7; F4IX97;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 2.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=BTB/POZ domain-containing protein At3g08570;
GN   OrderedLocusNames=At3g08570; ORFNames=F17O14.4;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   DOMAIN BTB.
RX   PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA   Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA   Vierstra R.D.;
RT   "Cullins 3a and 3b assemble with members of the broad
RT   complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT   ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL   J. Biol. Chem. 280:18810-18821(2005).
CC   -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC       of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC   -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00982}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAG51355.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC012562; AAG51355.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE74647.1; -; Genomic_DNA.
DR   RefSeq; NP_187469.4; NM_111691.5.
DR   AlphaFoldDB; Q9C9Z7; -.
DR   SMR; Q9C9Z7; -.
DR   PaxDb; Q9C9Z7; -.
DR   PRIDE; Q9C9Z7; -.
DR   ProteomicsDB; 242366; -.
DR   EnsemblPlants; AT3G08570.1; AT3G08570.1; AT3G08570.
DR   GeneID; 820004; -.
DR   Gramene; AT3G08570.1; AT3G08570.1; AT3G08570.
DR   KEGG; ath:AT3G08570; -.
DR   Araport; AT3G08570; -.
DR   TAIR; locus:2077763; AT3G08570.
DR   eggNOG; ENOG502QRW3; Eukaryota.
DR   HOGENOM; CLU_005994_6_0_1; -.
DR   InParanoid; Q9C9Z7; -.
DR   OMA; KSGCLEW; -.
DR   OrthoDB; 298243at2759; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q9C9Z7; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9C9Z7; baseline and differential.
DR   Genevisible; Q9C9Z7; AT.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR043454; NPH3/RPT2-like.
DR   InterPro; IPR027356; NPH3_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR32370; PTHR32370; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF03000; NPH3; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS51649; NPH3; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..617
FT                   /note="BTB/POZ domain-containing protein At3g08570"
FT                   /id="PRO_0000409573"
FT   DOMAIN          36..106
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          210..490
FT                   /note="NPH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT   REGION          505..525
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          585..617
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        505..521
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         431
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9FMF5"
SQ   SEQUENCE   617 AA;  69395 MW;  343EB60ACDCD1BEF CRC64;
     MGIISDNAQS HSSSSAPAPS IFSSSFATRI FSDVAGDITI VVDGESFLLH KFPLVARCGK
     IRKMVAEMKE SSSNLSHTEL RDFPGGSKTF ELAMKFCYGI NFEITISNVV AIRCAAGYLE
     MTEDFKEENL IARTETYLEQ VAFRSLEKSV EVLCSCETLY PQDIAETAHI PDRCVEAIAV
     NACREQLVLG LSRLNRGTES GELKRGDSPE WWIEDLSALR IDYYARVVSA MARTGLRSES
     IITSLMHYAQ ESLKGIRNCK ERTKLDSGTF ENEQRNVLEA IVSLFPNDNV PLSFLFGMLR
     VGITINVAIS CRLELERRIA QQLETVSLDD LLIPVVRDGD SMYDVDTVHR ILVCFLKKIE
     EEEEYDEDCC YENETENLTG SMCHSSLLKV GRIMDAYLAE IAPDPCLSLH KFMALIEILP
     DYARVMDDGL YRAIDMFLKG HPSLNEQECK SLCKFIDTQK LSQEACNHVA QNDRLPMQMV
     VRVLYSEQLR MKNVMSGESG EGLLLSSQKH SSENPSRAVS PRDTYASLRR ENRELKLEIS
     RVRVRLTELE KEQILMKQGM MEKSGHGGTL LTSLSKGIGR ISIFGGGPTE GKLRNANRKS
     KSRLERKTVR SRPESMF