ID   Y3866_ARATH             Reviewed;         582 AA.
AC   Q9C9Z0;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=Putative BTB/POZ domain-containing protein At3g08660;
GN   OrderedLocusNames=At3g08660; ORFNames=F17O14.13;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   DOMAIN BTB.
RX   PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA   Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA   Vierstra R.D.;
RT   "Cullins 3a and 3b assemble with members of the broad
RT   complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT   ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL   J. Biol. Chem. 280:18810-18821(2005).
CC   -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC       of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC   -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00982}.
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DR   EMBL; AC012562; AAG51353.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE74660.1; -; Genomic_DNA.
DR   RefSeq; NP_187478.1; NM_111700.2.
DR   AlphaFoldDB; Q9C9Z0; -.
DR   PaxDb; Q9C9Z0; -.
DR   PRIDE; Q9C9Z0; -.
DR   EnsemblPlants; AT3G08660.1; AT3G08660.1; AT3G08660.
DR   GeneID; 820013; -.
DR   Gramene; AT3G08660.1; AT3G08660.1; AT3G08660.
DR   KEGG; ath:AT3G08660; -.
DR   Araport; AT3G08660; -.
DR   TAIR; locus:2077868; AT3G08660.
DR   eggNOG; ENOG502QRW3; Eukaryota.
DR   HOGENOM; CLU_005994_6_0_1; -.
DR   InParanoid; Q9C9Z0; -.
DR   OMA; TFSTCIF; -.
DR   OrthoDB; 298243at2759; -.
DR   PhylomeDB; Q9C9Z0; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q9C9Z0; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9C9Z0; baseline and differential.
DR   Genevisible; Q9C9Z0; AT.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR043454; NPH3/RPT2-like.
DR   InterPro; IPR027356; NPH3_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR32370; PTHR32370; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF03000; NPH3; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS51649; NPH3; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..582
FT                   /note="Putative BTB/POZ domain-containing protein
FT                   At3g08660"
FT                   /id="PRO_0000409574"
FT   DOMAIN          36..103
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          196..466
FT                   /note="NPH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          558..582
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        563..582
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         407
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9FMF5"
SQ   SEQUENCE   582 AA;  65733 MW;  A697EA1CF60EA997 CRC64;
     MGSDSTLSLP SSSPPCNNRS SVPPTFTTRI FSDVAGDIIV VVDGESFLLH KFPLVARSGK
     MRKMVRDLKD SSSMIELRDF PGGPSTFELT MKFCYGINFD ITAFNVVSLR CAAGYLEMTE
     DYKEQNLIFR AENYLDQIVF RSFHESVLVL CSCETQEIAE TYEIPDRCVE AIAMNACRKQ
     LVSGLSEELK GRDCLEMWTE ELSALGIDYY VQVVSAMARL SVRSESIVAS LVHYAKTSLK
     GIIDRNCQEQ RKIVEAMVNL LPNDEKGSYS LSIIPLGFLF GMLKVGTIID IEISCRLELE
     RRIGHQLETA SLDDLLIPSV QNEDSMYDVD TVHRILTFFL ERIEEEDDEC GYDSDSTGQH
     SSLLKVGRIM DAYLVEIAPD PYLSLHKFTA IIETLPEHSR IVDDGIYRAI DMYLKAHPLL
     TEEERKKLCN FIDCKKLSQE ASNHVAQNDR LPVQMVVRVL YTEQLRLKKA LSGDSEEGSW
     VLPSGVQSRA VSPRDTYAAL RRENRELKLE ISRMRVRVSE LEKEHNLMKH EMMEKSGNNG
     GTFLTSLSKG IGRIATFGGE TRQKVNRKSR SVSERKSSRS GR