Y3868_ARATH
ID Y3868_ARATH Reviewed; 640 AA.
AC Q9C9Y8; Q93ZK0;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Probable inactive receptor kinase At3g08680;
DE Flags: Precursor;
GN OrderedLocusNames=At3g08680; ORFNames=F17O14.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-564, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=15308754; DOI=10.1105/tpc.104.023150;
RA Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
RT "Phosphoproteomics of the Arabidopsis plasma membrane and a new
RT phosphorylation site database.";
RL Plant Cell 16:2394-2405(2004).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=17397506; DOI=10.1111/j.1365-313x.2007.03028.x;
RA Shahollari B., Vadassery J., Varma A., Oelmueller R.;
RT "A leucine-rich repeat protein is required for growth promotion and
RT enhanced seed production mediated by the endophytic fungus Piriformospora
RT indica in Arabidopsis thaliana.";
RL Plant J. 50:1-13(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- INTERACTION:
CC Q9C9Y8; C0LGG6-2: At1g51890; NbExp=2; IntAct=EBI-16955024, EBI-20655952;
CC Q9C9Y8; Q9M0D8: LRR-RLK; NbExp=3; IntAct=EBI-16955024, EBI-16955231;
CC Q9C9Y8; C0LGP2: MEE39; NbExp=2; IntAct=EBI-16955024, EBI-20663701;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17397506}; Single-
CC pass membrane protein {ECO:0000269|PubMed:17397506}.
CC -!- DOMAIN: The protein kinase domain is predicted to be catalytically
CC inactive.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL09719.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC012562; AAG51359.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74662.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE74663.1; -; Genomic_DNA.
DR EMBL; AY057485; AAL09719.1; ALT_FRAME; mRNA.
DR EMBL; BT000497; AAN18066.1; -; mRNA.
DR RefSeq; NP_187480.1; NM_111702.2.
DR RefSeq; NP_974257.1; NM_202528.3.
DR AlphaFoldDB; Q9C9Y8; -.
DR SMR; Q9C9Y8; -.
DR BioGRID; 5350; 43.
DR IntAct; Q9C9Y8; 44.
DR STRING; 3702.AT3G08680.2; -.
DR iPTMnet; Q9C9Y8; -.
DR SwissPalm; Q9C9Y8; -.
DR PaxDb; Q9C9Y8; -.
DR PRIDE; Q9C9Y8; -.
DR ProteomicsDB; 242868; -.
DR EnsemblPlants; AT3G08680.1; AT3G08680.1; AT3G08680.
DR EnsemblPlants; AT3G08680.2; AT3G08680.2; AT3G08680.
DR GeneID; 820015; -.
DR Gramene; AT3G08680.1; AT3G08680.1; AT3G08680.
DR Gramene; AT3G08680.2; AT3G08680.2; AT3G08680.
DR KEGG; ath:AT3G08680; -.
DR Araport; AT3G08680; -.
DR TAIR; locus:2077898; AT3G08680.
DR eggNOG; ENOG502QT13; Eukaryota.
DR HOGENOM; CLU_000288_92_6_1; -.
DR InParanoid; Q9C9Y8; -.
DR OMA; CVGKSPE; -.
DR OrthoDB; 389502at2759; -.
DR PhylomeDB; Q9C9Y8; -.
DR PRO; PR:Q9C9Y8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9C9Y8; baseline and differential.
DR Genevisible; Q9C9Y8; AT.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009505; C:plant-type cell wall; HDA:TAIR.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF56112; SSF56112; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 1: Evidence at protein level;
KW ATP-binding; Leucine-rich repeat; Membrane; Nucleotide-binding;
KW Phosphoprotein; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..640
FT /note="Probable inactive receptor kinase At3g08680"
FT /id="PRO_0000317074"
FT TRANSMEM 260..280
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 93..115
FT /note="LRR 1"
FT REPEAT 117..138
FT /note="LRR 2"
FT REPEAT 139..162
FT /note="LRR 3"
FT REPEAT 163..185
FT /note="LRR 4"
FT REPEAT 186..206
FT /note="LRR 5"
FT DOMAIN 341..614
FT /note="Protein kinase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT REGION 222..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 289..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..640
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..640
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 347..355
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT BINDING 369
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT MOD_RES 343
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 364
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94F62"
FT MOD_RES 441
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
FT MOD_RES 514
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q94AG2"
FT MOD_RES 564
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:15308754"
SQ SEQUENCE 640 AA; 69406 MW; C974C668F07657CF CRC64;
MMKIIAAFLF LLVTTFVSRC LSADIESDKQ ALLEFASLVP HSRKLNWNST IPICASWTGI
TCSKNNARVT ALRLPGSGLY GPLPEKTFEK LDALRIISLR SNHLQGNIPS VILSLPFIRS
LYFHENNFSG TIPPVLSHRL VNLDLSANSL SGNIPTSLQN LTQLTDLSLQ NNSLSGPIPN
LPPRLKYLNL SFNNLNGSVP SSVKSFPASS FQGNSLLCGA PLTPCPENTT APSPSPTTPT
EGPGTTNIGR GTAKKVLSTG AIVGIAVGGS VLLFIILAII TLCCAKKRDG GQDSTAVPKA
KPGRSDNKAE EFGSGVQEAE KNKLVFFEGS SYNFDLEDLL RASAEVLGKG SYGTTYKAIL
EEGTTVVVKR LKEVAAGKRE FEQQMEAVGR ISPHVNVAPL RAYYFSKDEK LLVYDYYQGG
NFSMLLHGNN EGGRAALDWE TRLRICLEAA RGISHIHSAS GAKLLHGNIK SPNVLLTQEL
HVCVSDFGIA PLMSHHTLIP SRSLGYRAPE AIETRKHTQK SDVYSFGVLL LEMLTGKAAG
KTTGHEEVVD LPKWVQSVVR EEWTGEVFDV ELIKQQHNVE EEMVQMLQIA MACVSKHPDS
RPSMEEVVNM MEEIRPSGSG PGSGNRASSP EMIRSSDSPV
