ID   Y3874_MYCTU             Reviewed;         314 AA.
AC   P9WFH5; L0TDR0; O86359; Q7D4W6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase Rv3767c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Rv3767c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46594.1; -; Genomic_DNA.
DR   PIR; H70801; H70801.
DR   RefSeq; NP_218284.1; NC_000962.3.
DR   RefSeq; WP_003420557.1; NZ_NVQJ01000009.1.
DR   AlphaFoldDB; P9WFH5; -.
DR   SMR; P9WFH5; -.
DR   STRING; 83332.Rv3767c; -.
DR   PaxDb; P9WFH5; -.
DR   DNASU; 886101; -.
DR   GeneID; 886101; -.
DR   KEGG; mtu:Rv3767c; -.
DR   TubercuList; Rv3767c; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; DSMPPTL; -.
DR   PhylomeDB; P9WFH5; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..314
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase Rv3767c"
FT                   /id="PRO_0000361240"
FT   BINDING         132
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         161..162
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   314 AA;  34755 MW;  BACD884305460F6E CRC64;
     MPRTDNDSWA ITESVGATAL GVAAARAAET ESDNPLINDP FARIFVDAAG DGIWSMYTNR
     TLLAGATDLD PDLRAPIQQM IDFMAARTAF FDEYFLATAD AGVRQVVILA SGLDSRAWRL
     PWPDGTVVYE LDQPKVLEFK SATLRQHGAQ PASQLVNVPI DLRQDWPKAL QKAGFDPSKP
     CAWLAEGLVR YLPARAQDLL FERIDALSRP GSWLASNVPG AGFLDPERMR RQRADMRRMR
     AAAAKLVETE ISDVDDLWYA EQRTAVAEWL RERGWDVSTA TLPELLARYG RSIPHSGEDS
     IPPNLFVSAQ RATS