ID   Y388_MYCLE              Reviewed;         375 AA.
AC   Q49721; Q9CCV2;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Uncharacterized oxidoreductase ML0388;
DE            EC=1.-.-.-;
GN   OrderedLocusNames=ML0388; ORFNames=B1620_C2_193;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SIMILARITY: Belongs to the IMPDH/GMPR family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC29896.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; U00015; AAC43221.1; -; Genomic_DNA.
DR   EMBL; AL583918; CAC29896.1; ALT_INIT; Genomic_DNA.
DR   PIR; D86957; D86957.
DR   PIR; S72812; S72812.
DR   RefSeq; WP_041322396.1; NC_002677.1.
DR   AlphaFoldDB; Q49721; -.
DR   SMR; Q49721; -.
DR   STRING; 272631.ML0388; -.
DR   EnsemblBacteria; CAC29896; CAC29896; CAC29896.
DR   KEGG; mle:ML0388; -.
DR   Leproma; ML0388; -.
DR   eggNOG; COG0516; Bacteria.
DR   HOGENOM; CLU_064068_0_0_11; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0003938; F:IMP dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR005990; IMP_DH.
DR   InterPro; IPR005992; IMP_DH-rel2.
DR   InterPro; IPR001093; IMP_DH_GMPRt.
DR   PANTHER; PTHR11911; PTHR11911; 1.
DR   PANTHER; PTHR11911:SF85; PTHR11911:SF85; 1.
DR   Pfam; PF00478; IMPDH; 1.
DR   TIGRFAMs; TIGR01304; IMP_DH_rel_2; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..375
FT                   /note="Uncharacterized oxidoreductase ML0388"
FT                   /id="PRO_0000093784"
SQ   SEQUENCE   375 AA;  38924 MW;  CE22C3E84E1CA018 CRC64;
     MVEIGMGRVA RRTYELREIS IVPSRRTRSS KDVSTAWQLD AYRFEIPVVA HPTDALVSPE
     FAIELGRLGG LGVLNGEGLI GRHADVGAKV AQLIEAAEKE PEPATAVCLL QELHAAPLNP
     DLLGSAVARI REAGVTTAVR VSPQNAQVLT PVLLAAGIDL LVVQGSIVSA ECVASGGEPL
     NLKTFISELD VPVVAGGVLD HRTALHLMRT GAAGVIVGYG STRGATTSDE VLGISVPMAT
     AIADAAAARR EYLDETGGRY VHVLADGDIY TSGELAKAIA CGADAVVLGT PLAQSAEALG
     GGWFWPAAAA HPSLPRGALL QTAVGERPSL QQVLNGPSDN PFGTLNLVGG LRRSMAKAGY
     CDLKEFQKVG LIVSI