Y3893_DICDI
ID Y3893_DICDI Reviewed; 5875 AA.
AC Q54QG5;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Probable E3 ubiquitin-protein ligase DDB_G0283893;
DE EC=2.3.2.-;
DE AltName: Full=Probable E3 ubiquitin-protein transferase DDB_G0283893 {ECO:0000305};
GN ORFNames=DDB_G0283893;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Probable E3 ubiquitin-protein ligase. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- SIMILARITY: Belongs to the UBR4 family. {ECO:0000305}.
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DR EMBL; AAFI02000057; EAL65561.2; -; Genomic_DNA.
DR RefSeq; XP_638906.2; XM_633814.2.
DR STRING; 44689.DDB0267140; -.
DR PaxDb; Q54QG5; -.
DR PRIDE; Q54QG5; -.
DR EnsemblProtists; EAL65561; EAL65561; DDB_G0283893.
DR GeneID; 8624303; -.
DR KEGG; ddi:DDB_G0283893; -.
DR dictyBase; DDB_G0283893; -.
DR eggNOG; KOG1776; Eukaryota.
DR HOGENOM; CLU_223060_0_0_1; -.
DR InParanoid; Q54QG5; -.
DR OMA; NAEACMH; -.
DR PhylomeDB; Q54QG5; -.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-983168; Antigen processing: Ubiquitination & Proteasome degradation.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q54QG5; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.60.90; -; 1.
DR InterPro; IPR025704; E3_Ub_ligase_UBR4_C.
DR InterPro; IPR045189; UBR4-like.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR003126; Znf_UBR.
DR InterPro; IPR000433; Znf_ZZ.
DR InterPro; IPR043145; Znf_ZZ_sf.
DR PANTHER; PTHR21725; PTHR21725; 1.
DR Pfam; PF13764; E3_UbLigase_R4; 1.
DR Pfam; PF00569; ZZ; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SMART; SM00291; ZnF_ZZ; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
DR PROSITE; PS01357; ZF_ZZ_1; 1.
DR PROSITE; PS50135; ZF_ZZ_2; 1.
PE 3: Inferred from homology;
KW Coiled coil; Metal-binding; Reference proteome; Repeat; Transferase;
KW Ubl conjugation pathway; Zinc; Zinc-finger.
FT CHAIN 1..5875
FT /note="Probable E3 ubiquitin-protein ligase DDB_G0283893"
FT /id="PRO_0000369247"
FT DOMAIN 3313..3332
FT /note="UIM"
FT /evidence="ECO:0000305"
FT ZN_FING 2042..2113
FT /note="UBR-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00508"
FT ZN_FING 3226..3280
FT /note="ZZ-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT REGION 17..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 232..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 302..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 642..693
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 716..740
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1081..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1291..1367
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1806..1851
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1952..1982
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2008..2036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2109..2203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2893..2930
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3083..3119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3195..3214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3282..3312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3326..3359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3754..3776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4182..4237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4295..4323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4616..4671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1300..1328
FT /evidence="ECO:0000255"
FT COILED 4118..4146
FT /evidence="ECO:0000255"
FT COILED 4585..4618
FT /evidence="ECO:0000255"
FT COILED 5819..5846
FT /evidence="ECO:0000255"
FT COMPBIAS 17..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..250
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 253..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..320
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 321..342
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1294..1330
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1338..1367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1819..1851
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2118..2203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2904..2930
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3195..3210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3293..3307
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4182..4227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 3231
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 3234
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 3246
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 3249
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 3255
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 3258
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 3266
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
FT BINDING 3270
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00228"
SQ SEQUENCE 5875 AA; 658224 MW; 55704D9E63C6CA36 CRC64;
MDPDLLLAIA LSESLMDNNN NNNNNNNNNN NNNNNNNNNN NNNNSNNNNN KNVEMGEAEK
QPPEDKISTY FKELTGLLKK DTIVKNLKPL LALLKSKELL LDQIYFLSKI LESISFNIVF
NGKEKDKVEN EFEIFCKDTI EFCLNILEKW GNGDIDLSTI PNINNNNNND NNSNNKTDDN
NQSNNSKKLT PLTLLSVIDM LCCIEFPSTE IDKTFDNIPS FLNVSELDEI LDSNNQDNKE
NKKEDKESSK PIASSPIPIT TTNIEKPTIA TTTTTSTSNS NIFSQFLNEG LKVEGLNETM
IPSFKPSTLP PPPPTPTSTI TTQPLPSSTI TQPESYSNCG NGEGGMETFA KVNSNYFNNK
LFGSSRLLSI CSKLLVPYHA DLTSPSTVEK FETFKKNQTL IQDFMSNVQD IIFSEGFDSL
DKQTAPWTID FLGNLIGTLR SFQSFSISNN LSYYNNDSKF LSKHLFENIF EVLGSKLDYP
GLQIKAEIFF SLCILSDVNK MKIDIVKLLE RDQSTPLDKE YLVLNPQLII LAIDLVFKNI
REITEIQNNN NNNNNVDFNE LLKIDSTVDQ STITGVEKPT TKFLLSEPLD GTGVEGWFDF
SNENKQLFSK DSLFKLFIKP QLLDTLFNIL YLCYFKPTKS TTTTTTATTT TTTTTTNESI
PMETTRSSTP IPIVNNNNNN NDSKSNSKKS PPIKINDSYF GEDDLFGGLF DQSSTSIRSS
SNKVNEGTPK SSTTTTTTNA TIISTPANSN IKESSNDDGD HDEDIMKCKI FNLLSFIYLL
QDDPMYKEFT KNHLTLTHLR ILFTLIAPSS NPSIMAPKSK NSTVFKLLTN ICFLLCKNSI
ISDTLLDQFI GFVFTSVDSQ LLTLPKEQLA WIAWIFVKKQ STMVVGATNS VMVVSLWDGF
LKNSSRVIRE VSLVSSPFKE VISLDYILLL LFSFHTLDEK HRLGIVSTLC QSFNEIVCKV
KSDQSFLPNS LMLSRCLMVF NYILFNFETV NPILSKLFNS QLLSFKKSNY QVGEFYKLSI
VNLNYSGTIE KLIKKSAFIN NDGLIGLPEF YDLYFIPPPN NTLTSPSKSI NSSSNNILSP
ITPTNTTTTT TTTTPSTTSI PTNNEDWFNH SNNLEKITSL LQKSTNNDNC YEQFYNNIVS
LCSLTPTVKS TQDGSSLDSL YFDYIVASSL KFLSCLPLSL SFLKAIKDPQ TFTTVSNTSP
IFITYLKSIY PSQCNNPEIP WLAHTENILT HFKYNGGTPS DSSLRVNGIV QSSLAYLTKV
FDVGTSLNIN KKLAESSGNV DTSGGGDSYF DGWESLFNDD DDEEEDEEEE EEMDEDDSEN
DEDEDSEESE KEQNKDNLKS SSSTVPTTTT TAAAATTTAT ATTKESTIRS NISTLLPSLI
NFIIDTLGHY RGIYKKSLIE QLSNHSNALH VKLIQELYIL SSKTEVLEVM KSLDFSTDDR
NTVEKWDEEY KPDPLVPKDQ KQLFGWSVQP YNPSFTEGKV YSVALQSIIR LLLTLSNQAL
VHWDNVTETN PDSTKPILSK VSELIFEQVY ISTDRSFSFL KDHYDNYSSL ISGAQSGYLI
NQIKLANFES ISKILIDPTF SPSNNSSNKF LSENSYLLTV LIGYVDSLIS MSKLNGSHIY
CYYISGFNGS VARGTRDFEF VLPTGNLQLL ISVLFNNPCE KFNLKVLSAL VHFMSISTPS
EFFTSFRSHC ITTFSKIPIN DLKLWFEQKL LGINNFEKNS TATNGTEKMD IEIILNNNNN
NNNKVEEKSG KINSTVSIQE QIIRLIGLLI GNKDLSCYSK DYLQQQAAAA LAAKESEELL
QQQLLQESEG KKKKRSSGSS TPTKIPGKKT PITSGQDSNS SPALTASSSP PSLEFVDWDE
KVTSFALTLF DVLLSSLNNA FTVWIDQPKL LKGYFELLQF IAMGQHQLLK LFNEISNLSS
PLLTNPTIDQ LESLNLLVEF IENILDLSKS LKKPSSDQQH HSGGCHHSNH HHHHHHSRKD
EVMVDKSSIT NVVDEDILKD DVEVMDEEDE DELQYLSEDE KVVNGNENTG EEDDEERKLS
SKVCTYTFTK NDYIDQHWYF CYTCGLKFSE GCCSVCVKVC HKGHQVSYSR YSRFFCDCGA
GAGKGNPCKA LKPRLYSPPK QLQQQQQQQQ PQQPPQDQQK NVAAEQQPQQ QQEEQQVAST
TSSATNTNDQ PIIPDSLSSS SSNSSPSFNN NNNNNNNGTT GSGNTFSSIN NYFFNLPTQQ
DKEQLFNEIF NDKSNIISKL SELYPKLIEM YKKVQTDLIK PQSDSNSNKL EVFEESSTQS
ISSREIISKT DIFTTKKVSK NGTFEAKLKL EGVEGNQLKT FLSSGPIQRK AIASTSKGLL
AIAEGDSVSL FNSSKILDDD AQLDKHSFSK ALSKSSVAYP IVSMVFNPLN ERFLAVVGFK
EVKILTINQK DEIVDQLVID LSLDALGETI YIIKVEWIIG SQVELAIVTN EFIKIYDLSK
DNLSPIHFFS LLEDSIKDMC LVQKNGKNHI LALSNYGLLY FQAIEDSIDN ESCIMIETLQ
VPINKISAGV SVHYNIDLDL VIASYTNGEC YAFQVNDTMT NVTRSFPIMD PAKKLPMPAQ
YFINLSPMFP NVYACLAARG GYLLGFKMGT KDISIQNLKL TQRVEGMTIL NRSSPKLLIL
FDDGSIGRYD FNLENTIQQP LPTTSTTTDS INESDKKGLD ILLYLKSKYQ DSINKNNSGS
SINSSGNNVA TVSSSTTSTS AVIKSPPPLS SLLLQPTTTT TTSPVFPIDF FESTECITPN
VKYGGDPLQW FSQDVIKQKL ASNDEYIVCQ SLETLTLVIM NNNFNNAICG IRILVGNAST
KHIPTEIRVF NRTIQLKEGQ RRWYDIPFTT EETLRSIKKV SFTAGSTFTM GTSPIIDQVE
VYAKNKDSLG FNDSDDSDDE FPTVDENVTS SGLSTSAGGS GGGVAGTNDS TADKHTPLEI
VILHCFNSLK NYFSNHVAND DSQKFIELKE KTLSILPSMI TDSQLSFVRS SIKKLLKILS
TNSEHYQTLK HSIQLKYASQ TVSSILSNSG GTIPNSADLE KLDYLVAALK KISSSNPNNL
EKYLFKDHPN FLSDLLTIYR NTTSPSSSKG KSSSASASSS SSTTTATSTL PSNTQSGSNN
GAVSSNALLY SDSFISNLVQ LLWNCQRSKI FSTDLIFTLL KSLLSHSNEI IRTRSSLILV
SFISKSGNNS TVANLLPPPS SSSNENVVDN DNTNKENEGD IQMVDEVLFS CDLCNINPIT
GKRWNCSNCG DFDLCNQCYQ NPEKDHPKDH IFKEFIIDEP MKDGDEKEST NEPPQQQKQQ
DQQLQQDLQD DSEYDEELKI AISMSLNNNN NNNNNNESMD TSTLTTTTTT TNKTTPTTNE
EPMVGFIKLI IEEIIVSYEK GFSFMIPYMQ ILYSTILHNT TFILNNNQLS NQLVTTLVNL
ISKHKSNLSK FLSTKSNNLE GDILIFSLLS LLLDSDEQKR QKIQSKQTTT TAAAAATTTT
TATATVTTPS VVTTPHSLPS TLIYHLSKLF IDRDIIQLLR LWIEQLYTCI SESHGLSVGE
ERDSPFGALL VPSIDENQTL PKNRFTPFFG KYLPQSMGSI HLLLSKAIFK LMITFYRCER
RKKSITQTTP TLIKPSEWTN LICSFIHSKK TVSIVKYPKK LLFLIYQTKS SYYSIRDEFL
LKKKFAGILD LEGKTKGFSD EIGYDHLAKL ISYLTLMLEV ASDRPKSWQF FCAHNDVLPK
LYKILFNLAE EPSSLLLELL TYVFVDEIAE QPLSSTSQDT QQESSNNNNN NNSNDILMQD
VDTKAKHISI FLQEQYFNVL IFNILLESNS SDLRSIASSF IYYLWRSSNN EQRIFINKSL
WSKLNNVASY GKNASEFMDL LTYFLNETDS QSWKDQHNEF SNKLIESFKQ QNQISLNHPN
SQIYNSLGKI LEFDGYYLES EPCLVCNNPE VQYQTSRLES LKQEVKFSEY SQLIKFNGVY
NISKIMIQLH DVKKGKMIKT INLFYNNKPV ADIGDLKGKF NQWKKLKQVH FTPSQTEKAV
VFQIPISARN FMIEYFDFHD NLQAASSEKL QCPRCSRIVT DKHGICKNCH ENAYQCKHCR
NINYENLDAF LCNECGFCKH AKFDYSFVCK PTIAIEKIEN QEDHKRAIQT IEKESENAHK
KYQRLIGFKK VISGLINSFE TQEPWSKDDL IKSSGGTISI ANTSTNSTGS NNQSINSSSG
NISTNSSSSS SSSFGISNQS SSGNGGGGVG SGGGGVINQS GTSNNSSFLT LRINKKIGYL
SRLYERECRN IYEGLSKSVQ ILQTNRMEIS KYMNFISGGG QPSSNDKQQQ QQQQQQQSSR
QCPVSIHLRE ENKCYGCSNS YIEQVLCLLN SFCRNSELTP IKNLLIEKGL PKEIFFNNIH
HGKSIAKGWA KSSLSYLTKS NIDCTSMVNQ WIKDKIYYTL CYYSSLDVPN MVSSEISLLK
ECSSLSDNIW PQRLSFIMEL FFKALSSGSQ SPVVSEYIIL PCLKIIIYLC TLDRKGAFIT
KDAKDLEISQ KLLATRFEKL KSSKKQAIAL AATATATATA ANASLTSTIE KKIEALSSLL
SPNTVNNIAL SVASSLLSPQ QMQLQIQQQI ALQQQQIQQQ IQQQQQQLNE SVSGLKILSP
SSSSSSPSGV GATGSENGGG GSGSSSGSSV SGSGSISSSQ DPNILSIFDN DTSNAGANES
WDGDDNPIAN AWSSKYENYL SNFNVNSSIG EISKSLKPLS QDELKSKYFK RWYAQVKKRK
QQQQQQSSGI GYATQSSFEV LFEEKWLEKL LFNSTSSIRL EIITLMGILS KNSNSRSLKF
LDLLTKILPN ATEAGEYSAE FFGLFNSFIS TSQDRKIYLA VKGFIPFICD AIIKEIEHIK
SKEGSFSTDV SQGFVLKTLV AILKSFLDVP TLKAKMKKDN MLEKVLDAFL SLRGVIVQKN
KLTEDSVRYL QELMKSLNNE SVQDNKKFMA ANIKALAKYQ SDGRTPIFIF EQLCNIVCPT
KPDPIYQLIL FKAASQEEYI RGSMNRNPYT SNTFGGPLMR DVKNKICKAL DLGSFLDDDN
GMELLVDNKI IKLDLPIKKV YELVWKKSPQ ALRTADINIP MNVVYRLQGL DGEATEEIIE
TLNDNNSEEK DPEVEYEITS VMAECGGLES MISMIERIND FSIEKELAQL VIKLLYHCCK
IKINRQKLLT LNTVGRLLEK LKQAFHQPEL SEHLLVIIES VVSEANRDYL RGSNSSTSLS
HHKDINEAQE QMNMFLDKLN GAQVMSNPKI IQAITRIIPF LTYGHTEIMD YLVDFFTPYL
NFQEFDDSKS KDTNHVYHLD FFTKLMENTR PDSNGRSIRS IIIKRGITKS LVDYLLNYFP
ENGDKTSQEW LSSLEKPALP FVLVLLKGLA MGHEPTQNMT LESNLIKRIH ILEETAGTSA
KIGSLAENLL ESIAEGNEKT SKIVSDTRKE SKMEKLSHAQ KHREDVLKQL GLAQQGKHIM
ANVVPGSIED LDDDEGFTCM VCREGYSFKP TDVLGIYTFS KRIPLTSVGE TTCPPSSTTN
VAASLSLSPS SSGGGGGGAL YYGFTTVTHF NFIHFNCHRD ATKADRSMKV PKEEWEGAAL
RNQQTKCNGL FPVLPPKMNS DAFTPYSDKF WVNLNNISRV EGPKFRILSH DLKFLLIRLA
KDESFSTDSK GGGKESNIRI APMFVQLGMF LLDQKLVGGN SANQLRRPQF EKTLAQFTTL
PLETAITSMY QMLSDNVPYF LVVSIFLHSP KEFENQKFNY LTKLLAYAFV DYLTTNTKNG
LSSPDEPSKD KLFDITRPWL IFFSLLSKFH SIIKPSSCTE ENWIQETKNH LSTNCTKIQV
DVKELLNCFE NELKEFQDEM EFFDDEGLLK NVLLNNKDSN EYLLKLYKSV KSNKK
