ID   Y3895_MYCTU             Reviewed;         308 AA.
AC   P9WFH3; L0TGK0; P72053; Q7D4V4;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Putative S-adenosyl-L-methionine-dependent methyltransferase Rv3787c;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=Rv3787c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- FUNCTION: Exhibits S-adenosyl-L-methionine-dependent methyltransferase
CC       activity. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the UPF0677 family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46616.1; -; Genomic_DNA.
DR   PIR; G70696; G70696.
DR   RefSeq; NP_218304.1; NC_000962.3.
DR   RefSeq; WP_003420620.1; NZ_NVQJ01000009.1.
DR   AlphaFoldDB; P9WFH3; -.
DR   SMR; P9WFH3; -.
DR   STRING; 83332.Rv3787c; -.
DR   PaxDb; P9WFH3; -.
DR   DNASU; 886118; -.
DR   GeneID; 886118; -.
DR   KEGG; mtu:Rv3787c; -.
DR   TubercuList; Rv3787c; -.
DR   eggNOG; COG3315; Bacteria.
DR   OMA; RMAMETF; -.
DR   PhylomeDB; P9WFH3; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR011610; CHP00027_methylltransferase.
DR   InterPro; IPR007213; Ppm1/Ppm2/Tcmp.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   Pfam; PF04072; LCM; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00027; mthyl_TIGR00027; 1.
PE   1: Evidence at protein level;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..308
FT                   /note="Putative S-adenosyl-L-methionine-dependent
FT                   methyltransferase Rv3787c"
FT                   /id="PRO_0000361241"
FT   BINDING         131
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
FT   BINDING         160..161
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   308 AA;  33390 MW;  5865CF059D44E304 CRC64;
     MARTDDDSWD LATGVGATAT LVAAGRARAA RAAQPLIDDP FAEPLVRAVG VEFLTRWATG
     ELDAADVDDP DAAWGLQRMT TELVVRTRYF DQFFLDAAAA GVRQAVILAS GLDARGYRLP
     WPADTTVFEV DQPRVLEFKA QTLAGLGAQP TADLRMVPAD LRHDWPDALR RGGFDAAEPA
     AWIAEGLFGY LPPDAQNRLL DHVTDLSAPG SRLALEAFLG SADRDSARVE EMIRTATRGW
     REHGFHLDIW ALNYAGPRHE VSGYLDNHGW RSVGTTTAQL LAAHDLPAAP ALPAGLADRP
     NYWTCVLG