ID   Y389_CLOPE              Reviewed;         481 AA.
AC   P0C217; P30818;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Putative amino-acid transporter CPE0389;
GN   OrderedLocusNames=CPE0389;
OS   Clostridium perfringens (strain 13 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13 / Type A;
RX   PubMed=11792842; DOI=10.1073/pnas.022493799;
RA   Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA   Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT   "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT   eater.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
RN   [2]
RP   SIMILARITY TO OTHER MEMBERS OF THE FAMILY.
RX   PubMed=8382989; DOI=10.1002/pro.5560020103;
RA   Reizer J., Finley K., Kakuda D., McLeod C.L., Reizer A., Saier M.H. Jr.;
RT   "Mammalian integral membrane receptors are homologous to facilitators and
RT   antiporters of yeast, fungi, and eubacteria.";
RL   Protein Sci. 2:20-30(1993).
CC   -!- FUNCTION: Could be an amino acid transporter.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC       family. {ECO:0000305}.
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DR   EMBL; BA000016; BAB80095.1; -; Genomic_DNA.
DR   RefSeq; WP_003455623.1; NC_003366.1.
DR   AlphaFoldDB; P0C217; -.
DR   SMR; P0C217; -.
DR   STRING; 195102.gene:10489645; -.
DR   EnsemblBacteria; BAB80095; BAB80095; BAB80095.
DR   GeneID; 29572498; -.
DR   KEGG; cpe:CPE0389; -.
DR   HOGENOM; CLU_007946_1_2_9; -.
DR   OMA; YFWSSAY; -.
DR   Proteomes; UP000000818; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004754; Amino_acid_antiprt.
DR   Pfam; PF13520; AA_permease_2; 1.
DR   TIGRFAMs; TIGR00905; 2A0302; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Cell membrane; Membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..481
FT                   /note="Putative amino-acid transporter CPE0389"
FT                   /id="PRO_0000054253"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        36..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..147
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..176
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..261
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        422..442
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   481 AA;  52759 MW;  8C291010FDE2A91F CRC64;
     MNDNKKLGVI ALAGVVISAM LGGGVYNLPQ NMAQSASAGA ILISWIITGI GIWFIANTFR
     ILAAARPDAT TGIYTYGELG FGKFTGFLMA WGYWICNSFA NVGYAVLLMD SLNYFFPPYF
     KGGNNWLSIA CGSLVLWIIF FIVLAGVKQA SALNVIGTIG KLLPLAIFLL VLLFSFRFST
     FFTDFWGLKT VAKVHDTNLG GILPQVKSTM LVTLWVFTGI EGAVVVSGRA KSQKDVSKAT
     FLGFITCLLI YTLLSLLPLG VYSQGEISKM APPSTAAVLM DLIGNWGSVI MNLGVIIAIL
     SSWLIWTVML SELPFAAAQS GTFPKIFAKE NKNESPSFSL LASTIIMQII LILVHFAGNA
     WNMMLSITSV MALPCYLVST LYLFKITYKN ENYPTDIFAK RKYAMITAIL GSIYGVWLIY
     AAGINYMLIA IVIYALGIPV FIKARRETSP NEKEFTKVER YFAIVLIILA LIGLVYLFKF
     M