ID   Y392_MYCLE              Reviewed;         792 AA.
AC   Q49736;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Uncharacterized glycosyl hydrolase ML0392;
DE            EC=3.2.1.-;
GN   OrderedLocusNames=ML0392; ORFNames=B1620_F1_30;
OS   Mycobacterium leprae (strain TN).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium.
OX   NCBI_TaxID=272631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Smith D.R., Robison K.;
RL   Submitted (MAR-1994) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TN;
RX   PubMed=11234002; DOI=10.1038/35059006;
RA   Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA   Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA   Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA   Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA   Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA   Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA   Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA   Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA   Barrell B.G.;
RT   "Massive gene decay in the leprosy bacillus.";
RL   Nature 409:1007-1011(2001).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 65 family. {ECO:0000305}.
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DR   EMBL; U00015; AAC43240.1; -; Genomic_DNA.
DR   EMBL; AL583918; CAC29900.1; -; Genomic_DNA.
DR   PIR; S72831; S72831.
DR   RefSeq; NP_301380.1; NC_002677.1.
DR   RefSeq; WP_010907704.1; NC_002677.1.
DR   AlphaFoldDB; Q49736; -.
DR   SMR; Q49736; -.
DR   STRING; 272631.ML0392; -.
DR   CAZy; GH65; Glycoside Hydrolase Family 65.
DR   EnsemblBacteria; CAC29900; CAC29900; CAC29900.
DR   KEGG; mle:ML0392; -.
DR   PATRIC; fig|272631.5.peg.660; -.
DR   Leproma; ML0392; -.
DR   eggNOG; COG1554; Bacteria.
DR   HOGENOM; CLU_006285_2_2_11; -.
DR   OMA; EAYCIPF; -.
DR   Proteomes; UP000000806; Chromosome.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0016757; F:glycosyltransferase activity; IEA:UniProt.
DR   GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 1.50.10.10; -; 1.
DR   Gene3D; 2.70.98.40; -; 1.
DR   InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR   InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR   InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR   InterPro; IPR005194; Glyco_hydro_65_C.
DR   InterPro; IPR005195; Glyco_hydro_65_M.
DR   InterPro; IPR005196; Glyco_hydro_65_N.
DR   InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR   InterPro; IPR017045; Malt_Pase/Glycosyl_Hdrlase.
DR   Pfam; PF03633; Glyco_hydro_65C; 1.
DR   Pfam; PF03632; Glyco_hydro_65m; 1.
DR   Pfam; PF03636; Glyco_hydro_65N; 1.
DR   PIRSF; PIRSF036289; Glycosyl_hydrolase_malt_phosph; 1.
DR   SUPFAM; SSF48208; SSF48208; 1.
DR   SUPFAM; SSF74650; SSF74650; 1.
PE   3: Inferred from homology;
KW   Glycosidase; Hydrolase; Reference proteome.
FT   CHAIN           1..792
FT                   /note="Uncharacterized glycosyl hydrolase ML0392"
FT                   /id="PRO_0000108020"
FT   REGION          753..792
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        488
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250|UniProtKB:Q32M88"
FT   BINDING         361..362
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:D6XZ22"
FT   BINDING         590..591
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:D6XZ22"
SQ   SEQUENCE   792 AA;  88087 MW;  DFAFCBBCCA4E20C8 CRC64;
     MITEEAFPVE PWQIRETRLD LNLLAQSESL FALSNGHIGL RGNLDEGEPY GLPGTYLNSF
     YEIRPLPYAE AGYGYPEAGQ TVVDVTNGKI LRLFVEDEPF DVRYGEVIFH ERVLDLCAGT
     LTRRANWRSP ADKQVKVVST RLVSLAHRSV AAIEYVVEAL DKFVRVTVQS ELVSNEDQPE
     TSGDPRVSAI LDNPLEAVEH EATERGGLLM HRTRASSLMM AAGMDHEVEV PGRVEITTDA
     RPDLARTTVI CGLRPGQKLR IVKYLAYGWS SLRSRPALHD QATAALHTAR YSGWQGLLDA
     QRAYLNEFWD SADVEVEGDP ESQQAVRFGL FHLLQASARA ERRAIPSKGL TGTGYDGHAF
     WDTEGFVLPV LTYTAPHAVA DALRWRASTL QLAKDRAAEL GLDGASFCWR TIRGQECSAY
     WPAGTAAWHI NADIAMAFER YRIVTGDHSL EEECGLAVLI ETARLWLSLG HHDRHGVWHL
     DGVTGPDEYT AVVRDNVFTN LMAASNLITA ADACLRQPEA AKAMGVTTEE MAAWRDAADA
     ANIPYDDELG VHQQCEGFTT FAEWDFEANT TYPLFLHEAY VRLYPAQVIK QADLVLAMQW
     QSHAFTPEQK ARNVDYYERR MVRDSSLSAC TQAVMCAEVG HLELAHDYAY EAALIDLRDL
     HRNTRDGLHM ASLAGAWTAL VGGFGGLRDD EGILSIDPQL PHGISRLRFR LRWRGFRLTV
     DARHADVTYT LRDGPGGELT IRHAGEHLTL KSDSPSTIAV RDRKPLLPPP SQPPGREPVS
     RRHKSLIISA AR