Y3934_DICDI
ID Y3934_DICDI Reviewed; 1713 AA.
AC Q54B29;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Uncharacterized membrane protein DDB_G0293934;
GN ORFNames=DDB_G0293934;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
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DR EMBL; AAFI02000224; EAL60466.1; -; Genomic_DNA.
DR RefSeq; XP_628887.1; XM_628885.1.
DR AlphaFoldDB; Q54B29; -.
DR SMR; Q54B29; -.
DR STRING; 44689.DDB0231107; -.
DR PaxDb; Q54B29; -.
DR EnsemblProtists; EAL60466; EAL60466; DDB_G0293934.
DR GeneID; 8629502; -.
DR KEGG; ddi:DDB_G0293934; -.
DR dictyBase; DDB_G0293934; -.
DR eggNOG; KOG3661; Eukaryota.
DR HOGENOM; CLU_240514_0_0_1; -.
DR InParanoid; Q54B29; -.
DR OMA; WILYRQN; -.
DR PRO; PR:Q54B29; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0016540; P:protein autoprocessing; IBA:GO_Central.
DR InterPro; IPR024061; NDT80_DNA-bd_dom.
DR InterPro; IPR008967; p53-like_TF_DNA-bd.
DR InterPro; IPR030392; S74_ICA.
DR Pfam; PF13884; Peptidase_S74; 1.
DR SUPFAM; SSF49417; SSF49417; 1.
DR PROSITE; PS51688; ICA; 1.
DR PROSITE; PS51517; NDT80; 1.
PE 4: Predicted;
KW DNA-binding; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..1713
FT /note="Uncharacterized membrane protein DDB_G0293934"
FT /id="PRO_0000371410"
FT TRANSMEM 1416..1436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1447..1467
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1473..1493
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 1240..1355
FT /note="Peptidase S74"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01025"
FT DNA_BIND 544..825
FT /note="NDT80"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00850"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 79..200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 309..557
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 713..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1596..1634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1646..1665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 309..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 503..557
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 859..935
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1596..1612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1613..1634
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 1239..1240
FT /note="Cleavage; by autolysis"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01025"
SQ SEQUENCE 1713 AA; 189372 MW; 9A383A0B0CCC2A3C CRC64;
MNENEFSTNS LINQQGTNNN NNNNTNNNIT NINFGTENNN NSPIINNNNN NNNNNNNNIN
IVESPPLVIR QQQLFNNFQQ LNTPPTTPNT STPSTPTSSR NNNNNNNNNI DFYNSKFLPP
KPKSLNNSGN YLNNNNNINN NNNNNNNNHH NNNNNNNNNI NFTNLSNSGN SLKFNKNMSD
ITNDNSNSSS NAGSNSKLSN SNGCSNLLTS SFNNILNSTN VQVVSGNNNY HNGNNENGNN
TFHVGNNLNN NNNNNNIGSS GGNNSHHHHN HSHHNSGNHQ NGGSNGQPLS YSYDNLFNNL
YADIQHPHQY LSNHSGNNIN NTSQSNNNNN NNNNNNNNNN NNNNNNNNNS NNNNNNNSNN
NNNNNNNNNN NNNNNNNNNS NNSNSNNTNN SNSNHNNNNN HNNNNNNNNN NSNNNNIHGN
SNNNNNNNHG SSYVTPSSDI SSPSPPSSTS MASIVSSPPV QVSPLQSPAS HLSPMSPSNN
FGGNHNNYNH AHHSHHNNHA HHNTHNYNNN NNNNNNNNNN NNNNNNNSNN SNNNSNTNNN
GNNGNNSNNN NNHPMSHIDA FNKVTQLTST TSTSIPKKLK RDYEQTFSKD EWEDYTPPSK
YFQLFSYSKS EMSGSFSFKV KRTDKNIQYS ELDSAWILYR QNRFQVDCDL IGSLESWSNL
DRNNTIFVNS NNNNNNNNNN NNNNDNGDLS EVNGLFFTLY VLKFTDANNI QSSNDQNDRV
PIHQLGGATG KKDRLTVEPS PVVKGRGCWN KLQFGSATSN NARVHPDQPN PNQQFFRVVI
TLNAVIDKNF ENQNFTTPQF YPIQSKISPP MIVRGQNPGR FLNHDKSLKK DPNSSPNGGK
GGGGSGSGGM GGGMGGGMGN NGSSGSSSNG GYGNGSANKH MKTFLNTSNS DNSDDDQSPT
TTTTTTTTTT TPTPTPTTTT TTTNETTTST IPTTTPLPKT PSPTLTAPSI TTTLDGNNTS
IFNGPCDLTT IDPLTFSNLL QDPLILGQTM MVDIDSNNIL NNINTNSTIN NNNNNNNTNS
DDLMVYDPQT TLDLANLIQQ QQLHQQQQLS NLKAAQAAAA IAASIANTTS TPNTTSTDIQ
NPFNFLNNPL TNTNIQQSLF LNQNIPGVST NQMINSLNLA NGLLQNTTTP QSHHTILEIN
NNHHHHQQQQ QQPITTTTTT TTTIPSTPQP SQQSMTNSGG SSSTNSSISR KNKFAKWNTN
PFMEEVIYTN NKVGINTTTP TQALAVNGNI LVTGELFKPS DQRIKSNIRL DNTDHWDKIN
RLKIYDYDRK KMMGYDDPNN NGTTQESTTV KEKGFLAQEV KEVLPNAVKV AGEVKLQDGT
TVPNLLVVND RVLLLENIGA TQQIGRSLKK EKDHIVKIDR DLDRVKIEGS REKHVILTRM
QDMVNFMHSE ESERSNNNNE ESCVYCSLMG FGPAWTMFVF GFFIPICWII GSFYLFSPTR
VKWVSGLMNF VATIIFILAL SLMTFYVPEL AALIIAPALI VMGFVVCILV GFFRQRNREK
KRYLRERIKL MQADGYKNLA DHVSSFRVDY NQHQAKANNN MLKKKKKRIQ MEKLNSQRNY
GGINTTDKIN NSNINNIGIN NPNNIQNNQI NNILNNSNNN INNNNQERLS DSSKSSFIDD
FKKSSSNNHK DFHEIPLQEI IQSIGIKGKK QSSSSAKTRS LSSSNLVNSV NSNLVNSTNS
NNTSILLKSH NSNSPLFNST PTPTNVVFNS IEV
