ID   Y396_HAEIN              Reviewed;         404 AA.
AC   P44683;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 109.
DE   RecName: Full=Probable ribosomal oxygenase HI_0396;
DE            Short=ROX;
DE            EC=1.14.11.-;
GN   OrderedLocusNames=HI_0396;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=10675023;
RX   DOI=10.1002/(sici)1522-2683(20000101)21:2<411::aid-elps411>3.0.co;2-4;
RA   Langen H., Takacs B., Evers S., Berndt P., Lahm H.W., Wipf B., Gray C.,
RA   Fountoulakis M.;
RT   "Two-dimensional map of the proteome of Haemophilus influenzae.";
RL   Electrophoresis 21:411-429(2000).
CC   -!- FUNCTION: Oxygenase that catalyzes the hydroxylation of a ribosomal
CC       protein. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC         Evidence={ECO:0000250|UniProtKB:P27431};
CC       Note=Binds 1 Fe(2+) ion per subunit. {ECO:0000250|UniProtKB:P27431};
CC   -!- SIMILARITY: Belongs to the ROX family. {ECO:0000305}.
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DR   EMBL; L42023; AAC22055.1; -; Genomic_DNA.
DR   PIR; A64151; A64151.
DR   RefSeq; NP_438558.1; NC_000907.1.
DR   RefSeq; WP_005693774.1; NC_000907.1.
DR   AlphaFoldDB; P44683; -.
DR   SMR; P44683; -.
DR   STRING; 71421.HI_0396; -.
DR   DNASU; 950708; -.
DR   EnsemblBacteria; AAC22055; AAC22055; HI_0396.
DR   KEGG; hin:HI_0396; -.
DR   PATRIC; fig|71421.8.peg.415; -.
DR   eggNOG; COG2850; Bacteria.
DR   HOGENOM; CLU_039125_1_0_6; -.
DR   OMA; FPHDGFT; -.
DR   PhylomeDB; P44683; -.
DR   BioCyc; HINF71421:G1GJ1-411-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016706; F:2-oxoglutarate-dependent dioxygenase activity; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR003347; JmjC_dom.
DR   InterPro; IPR039994; JmjC_protein.
DR   PANTHER; PTHR13096; PTHR13096; 1.
DR   Pfam; PF08007; Cupin_4; 1.
DR   SMART; SM00558; JmjC; 1.
DR   PROSITE; PS51184; JMJC; 1.
PE   1: Evidence at protein level;
KW   Dioxygenase; Iron; Metal-binding; Oxidoreductase; Reference proteome.
FT   CHAIN           1..404
FT                   /note="Probable ribosomal oxygenase HI_0396"
FT                   /id="PRO_0000168831"
FT   DOMAIN          102..231
FT                   /note="JmjC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00538"
FT   BINDING         135
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:P27431"
FT   BINDING         137
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:P27431"
FT   BINDING         199
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:P27431"
SQ   SEQUENCE   404 AA;  46419 MW;  A3FF26064D3F8B4C CRC64;
     MTALSSVDFC LPEHITPEIF LRDYWQKKPL VIRNGLPEIV GQFEPQDIIE LAQNEDVTAR
     LVKTFSDDDW KVFFSPLSEK DFQKLPEKWS VLVQNLEQWS PELGQLWNKF GFIPQWQRDD
     IMVSYAPKGG SVGKHYDEYD VFLVQGYGHR RWQVGKWCDA STEFKPNQSI RIFDDMGELV
     IDEVMNPGDI LYIPARMAHY GVAEDDCLTF SFGLRYPNLS NLIDGISKGF CHQDPDLNLS
     EFDLPLRLSQ SEQRTGKLAD ENIQAMKQLL LDKLAHSEAF DTLFKQAVAS AVSSRRYELL
     VSDEMCDPDE VRSILEEDGA FLSQDNNCKL LYTENPLRIY ANGEWLDELN IIESEVLKRL
     SDGESLDWAF LSDLANKTED PETSMDLLLD SICNWVDDGW ALIE