ID   Y3976_STRGG             Reviewed;         416 AA.
AC   B1VS51;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   20-MAY-2008, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Uncharacterized N-acetyltransferase SGR_3976 {ECO:0000255|HAMAP-Rule:MF_01812};
DE            EC=2.3.1.- {ECO:0000255|HAMAP-Rule:MF_01812};
GN   OrderedLocusNames=SGR_3976;
OS   Streptomyces griseus subsp. griseus (strain JCM 4626 / NBRC 13350).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=455632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM 4626 / NBRC 13350;
RX   PubMed=18375553; DOI=10.1128/jb.00204-08;
RA   Ohnishi Y., Ishikawa J., Hara H., Suzuki H., Ikenoya M., Ikeda H.,
RA   Yamashita A., Hattori M., Horinouchi S.;
RT   "Genome sequence of the streptomycin-producing microorganism Streptomyces
RT   griseus IFO 13350.";
RL   J. Bacteriol. 190:4050-4060(2008).
CC   -!- SUBUNIT: Homohexamer; trimer of dimers. {ECO:0000255|HAMAP-
CC       Rule:MF_01812}.
CC   -!- SIMILARITY: Belongs to the acetyltransferase Eis family.
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DR   EMBL; AP009493; BAG20805.1; -; Genomic_DNA.
DR   RefSeq; WP_012380280.1; NC_010572.1.
DR   AlphaFoldDB; B1VS51; -.
DR   SMR; B1VS51; -.
DR   STRING; 455632.SGR_3976; -.
DR   EnsemblBacteria; BAG20805; BAG20805; SGR_3976.
DR   GeneID; 6209377; -.
DR   KEGG; sgr:SGR_3976; -.
DR   eggNOG; COG4552; Bacteria.
DR   HOGENOM; CLU_050659_0_0_11; -.
DR   OMA; RRPWCPD; -.
DR   OrthoDB; 1497065at2; -.
DR   Proteomes; UP000001685; Chromosome.
DR   GO; GO:0008080; F:N-acetyltransferase activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.30.1050.10; -; 1.
DR   HAMAP; MF_01812; Eis; 1.
DR   InterPro; IPR041380; Acetyltransf_17.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   InterPro; IPR025559; Eis_dom.
DR   InterPro; IPR000182; GNAT_dom.
DR   InterPro; IPR022902; NAcTrfase_Eis.
DR   InterPro; IPR036527; SCP2_sterol-bd_dom_sf.
DR   Pfam; PF17668; Acetyltransf_17; 1.
DR   Pfam; PF13530; SCP2_2; 1.
DR   SUPFAM; SSF55718; SSF55718; 1.
DR   SUPFAM; SSF55729; SSF55729; 1.
DR   PROSITE; PS51186; GNAT; 1.
PE   3: Inferred from homology;
KW   Acyltransferase; Transferase.
FT   CHAIN           1..416
FT                   /note="Uncharacterized N-acetyltransferase SGR_3976"
FT                   /id="PRO_1000187721"
FT   DOMAIN          3..150
FT                   /note="N-acetyltransferase"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01812"
FT   ACT_SITE        124
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01812"
FT   ACT_SITE        416
FT                   /note="Proton acceptor; via carboxylate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01812"
FT   BINDING         83..85
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01812"
FT   BINDING         91..96
FT                   /ligand="acetyl-CoA"
FT                   /ligand_id="ChEBI:CHEBI:57288"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01812"
SQ   SEQUENCE   416 AA;  44975 MW;  11F0CA64704A2A61 CRC64;
     MSLDVRTITP SESAEWMRAV STGFLTAGTP SEELVADRFA GADLSRTQGA FEAGRCVATF
     RSFAQELTVV GGATVAADAI SGVTVTPTHR RRGLLSRMMA TDLAAAKERG EPVASLIAAE
     YPIYGRYGFG PAAWTSVWEV SVYRAGLDAR RSGQPADGGR IEMVDGADVR KLGPEVHGAL
     AARQPGVVTR DERWWRQRTG AAPSSAHEKW TEPFYVVHRA ADGTVDGLMT YGTDDTWGDA
     KQPLNTASVR DMIALNPAAE RALWHYLCSI DWITTIRSGY RAPDDLLPLL LPDPRAARMI
     TNADWLWLRM LDVPRALEAR TYGTEASLVL EVRDDAGLAG GRFLLDASTG GARCVSTTRS
     ADLVLGVAEL ATLYLGDESV RRLVDLGRAE ESRAGAATTA DAVFRTGRRP WCPDVF