ID   Y397_CLOPE              Reviewed;         452 AA.
AC   P50487; P94653;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 3.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Putative purine permease CPE0397;
GN   Name=cpx; OrderedLocusNames=CPE0397;
OS   Clostridium perfringens (strain 13 / Type A).
OC   Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=195102;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=13 / Type A;
RX   PubMed=11792842; DOI=10.1073/pnas.022493799;
RA   Shimizu T., Ohtani K., Hirakawa H., Ohshima K., Yamashita A., Shiba T.,
RA   Ogasawara N., Hattori M., Kuhara S., Hayashi H.;
RT   "Complete genome sequence of Clostridium perfringens, an anaerobic flesh-
RT   eater.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:996-1001(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-452.
RC   STRAIN=ATCC 12917 / NCTC 8239 / Type A;
RX   PubMed=8162194; DOI=10.1099/13500872-140-1-97;
RA   Brynestad S., Iwanejko L.A., Stewart G.S., Granum P.E.;
RT   "A complex array of Hpr consensus DNA recognition sequences proximal to the
RT   enterotoxin gene in Clostridium perfringens type A.";
RL   Microbiology 140:97-104(1994).
RN   [3]
RP   SEQUENCE REVISION.
RA   Brynestad S.;
RL   Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC       2.A.40) family. {ECO:0000305}.
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DR   EMBL; BA000016; BAB80103.1; -; Genomic_DNA.
DR   EMBL; X71844; CAA50688.1; -; Genomic_DNA.
DR   RefSeq; WP_003473969.1; NC_003366.1.
DR   AlphaFoldDB; P50487; -.
DR   SMR; P50487; -.
DR   STRING; 195102.gene:10489653; -.
DR   TCDB; 2.A.40.2.1; the nucleobase/ascorbate transporter (nat) or nucleobase:cation symporter-2 (ncs2) family.
DR   EnsemblBacteria; BAB80103; BAB80103; BAB80103.
DR   KEGG; cpe:CPE0397; -.
DR   HOGENOM; CLU_017959_8_2_9; -.
DR   OMA; RKSAPFF; -.
DR   Proteomes; UP000000818; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:UniProt.
DR   InterPro; IPR006043; NCS2.
DR   InterPro; IPR017588; UacT-like.
DR   InterPro; IPR006042; Xan_ur_permease.
DR   Pfam; PF00860; Xan_ur_permease; 1.
DR   TIGRFAMs; TIGR00801; ncs2; 1.
DR   TIGRFAMs; TIGR03173; pbuX; 1.
DR   PROSITE; PS01116; XANTH_URACIL_PERMASE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..452
FT                   /note="Putative purine permease CPE0397"
FT                   /id="PRO_0000165974"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        83..103
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        108..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        172..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        348..368
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        412..432
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        143..146
FT                   /note="VTGT -> ARVP (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        186
FT                   /note="V -> I (in Ref. 2; CAA50688)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        225
FT                   /note="P -> S (in Ref. 2; CAA50688)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        266
FT                   /note="C -> M (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        269..278
FT                   /note="AIGETSNIDI -> SYWRDILLLIF (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        449
FT                   /note="K -> T (in Ref. 2; CAA50688)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   452 AA;  46776 MW;  5CDAA29505357279 CRC64;
     MEKQNLKNTE VNLIYGVDDD LDLPKKVLFG LQHIFAAFGG IIVVPLVIAT SLGFDSKVTT
     ALISASILGS GLATIIQAKG VGKVGARVAC IMGTDFTFVS PAISVGSVLG LPGIIGATIL
     GSLFEVILSF FIKPLMKFFP PLVTGTVVAL IGLTLLPVSI DWAAGGAGSA NYASLENLAV
     AMFVLVITLL LNNYGKGMIS SASILIGIVV GYIVCIPLGL VDFTPVKEAS WLSFPKILEF
     GVTFDAKAVM AFIPAYFVAT IGTVGCLKAI GETSNIDIGD KRVAAGVLSD GVGSALGGLV
     GSCPNTSFSQ NIGIISLTKV ASRHVAVMAG ILLVILGFLP KVAAIITGIP NPVLGGVGIM
     MFGTVAAAGI RTLSNIKLTE RNLLIIAISM GLGLGVTFRP DVIHNLPEAI RMIFSSGIST
     GTIAALILNA VLKESPTSME FENMYDEEKK AS