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Y3985_ARATH
ID   Y3985_ARATH             Reviewed;         554 AA.
AC   Q9LT24; Q6NKN4;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=BTB/POZ domain-containing protein At3g19850;
GN   OrderedLocusNames=At3g19850; ORFNames=MPN9.9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA   Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT   features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT   clones.";
RL   DNA Res. 7:131-135(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RA   Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA   Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA   Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA   Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA   Shinozaki K.;
RT   "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL   Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 34-554.
RC   STRAIN=cv. Columbia;
RA   Cheuk R., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA   Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA   Shinozaki K., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   DOMAIN BTB.
RX   PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA   Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA   Vierstra R.D.;
RT   "Cullins 3a and 3b assemble with members of the broad
RT   complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT   ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL   J. Biol. Chem. 280:18810-18821(2005).
CC   -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC       protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC       ubiquitination and subsequent proteasomal degradation of target
CC       proteins. {ECO:0000250}.
CC   -!- PATHWAY: Protein modification; protein ubiquitination.
CC   -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC       of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC   -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00982}.
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DR   EMBL; AB025631; BAB01299.1; -; Genomic_DNA.
DR   EMBL; CP002686; AEE76299.1; -; Genomic_DNA.
DR   EMBL; AK175315; BAD43078.1; -; mRNA.
DR   EMBL; AK176753; BAD44516.1; -; mRNA.
DR   EMBL; AK176817; BAD44580.1; -; mRNA.
DR   EMBL; AK222235; BAD95418.1; -; mRNA.
DR   EMBL; BT012660; AAT06479.1; -; mRNA.
DR   RefSeq; NP_188619.2; NM_112875.4.
DR   AlphaFoldDB; Q9LT24; -.
DR   SMR; Q9LT24; -.
DR   STRING; 3702.AT3G19850.1; -.
DR   PaxDb; Q9LT24; -.
DR   PRIDE; Q9LT24; -.
DR   ProteomicsDB; 243151; -.
DR   EnsemblPlants; AT3G19850.1; AT3G19850.1; AT3G19850.
DR   GeneID; 821522; -.
DR   Gramene; AT3G19850.1; AT3G19850.1; AT3G19850.
DR   KEGG; ath:AT3G19850; -.
DR   Araport; AT3G19850; -.
DR   TAIR; locus:2092301; AT3G19850.
DR   eggNOG; ENOG502QPQT; Eukaryota.
DR   HOGENOM; CLU_005994_8_0_1; -.
DR   InParanoid; Q9LT24; -.
DR   OMA; LHCCAVF; -.
DR   OrthoDB; 539292at2759; -.
DR   PhylomeDB; Q9LT24; -.
DR   UniPathway; UPA00143; -.
DR   PRO; PR:Q9LT24; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9LT24; baseline and differential.
DR   Genevisible; Q9LT24; AT.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR043454; NPH3/RPT2-like.
DR   InterPro; IPR027356; NPH3_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   PANTHER; PTHR32370; PTHR32370; 1.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF03000; NPH3; 1.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS51649; NPH3; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ubl conjugation pathway.
FT   CHAIN           1..554
FT                   /note="BTB/POZ domain-containing protein At3g19850"
FT                   /id="PRO_0000409575"
FT   DOMAIN          5..80
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   DOMAIN          207..465
FT                   /note="NPH3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT   REGION          522..554
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        522..540
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   554 AA;  62991 MW;  93C37A098725927B CRC64;
     MSLCCDLQIN LNNQFTFFVN QDLISEYSGF LRKMIKQSNK KKKNHKNSRI IIEVEDFPGG
     SDGFDLVLRF CYGGGISIDV SNVSILHCSS VFLEMTEKLC SSNLLLRTEK FLEGMFYWSW
     NDIVLCLKSC EQVFLHADSY GLVDKLVFGV LAKIPQNSDV SHVFSSSSPS SSASASASSQ
     SPETAMIRSY SDKRSTSRSF SCRTSNEWWF DDMSILGPKI IEKLINTLGA HDKNNDSLVL
     TKFLLHYLKT KVPNKSTNKL EYSGLADTAV QGVVFAAKTA FSCRKMFWVL RVLSGFSISK
     ESRIGLERVI GEMLDQATLD DLLIPAGGKG EKGVYDVDLV IRLLKVFVRI GNTEEGDQNL
     RMRRIGKLID KYLREISPDQ NLKVSKFLEV AESLPDSARD WFDGLYRAIN IYLESHPKLS
     SEDRTKLCRC LNYKKLTLDT CKQLAKNPKI PPNIAVQALK SQQLSNETRP HSREDKNKVN
     KIWNSRKYLE EKPILVCLKG FDMSEKFEDD LMMNLERKQW NNSEKVSKEK KSEVMSRSVR
     HGHTHSSSSF PRLC
 
 
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