Y3990_ARATH
ID Y3990_ARATH Reviewed; 517 AA.
AC Q9M2W8;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=BTB/POZ domain-containing protein At3g49900;
GN OrderedLocusNames=At3g49900; ORFNames=T16K5.250;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP DOMAIN BTB.
RX PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA Vierstra R.D.;
RT "Cullins 3a and 3b assemble with members of the broad
RT complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL J. Biol. Chem. 280:18810-18821(2005).
CC -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9M2W8-1; Sequence=Displayed;
CC -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00982}.
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DR EMBL; AL132965; CAB66928.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE78603.1; -; Genomic_DNA.
DR PIR; T46056; T46056.
DR RefSeq; NP_190559.1; NM_114850.2. [Q9M2W8-1]
DR AlphaFoldDB; Q9M2W8; -.
DR iPTMnet; Q9M2W8; -.
DR PaxDb; Q9M2W8; -.
DR PRIDE; Q9M2W8; -.
DR ProteomicsDB; 242368; -. [Q9M2W8-1]
DR EnsemblPlants; AT3G49900.1; AT3G49900.1; AT3G49900. [Q9M2W8-1]
DR GeneID; 824152; -.
DR Gramene; AT3G49900.1; AT3G49900.1; AT3G49900. [Q9M2W8-1]
DR KEGG; ath:AT3G49900; -.
DR Araport; AT3G49900; -.
DR eggNOG; ENOG502QYIX; Eukaryota.
DR InParanoid; Q9M2W8; -.
DR OMA; EDYFFQE; -.
DR PhylomeDB; Q9M2W8; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9M2W8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M2W8; baseline and differential.
DR Genevisible; Q9M2W8; AT.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR043454; NPH3/RPT2-like.
DR InterPro; IPR027356; NPH3_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR32370; PTHR32370; 1.
DR Pfam; PF03000; NPH3; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS51649; NPH3; 1.
PE 3: Inferred from homology;
KW Alternative splicing; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..517
FT /note="BTB/POZ domain-containing protein At3g49900"
FT /id="PRO_0000409579"
FT DOMAIN 67..130
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DOMAIN 224..307
FT /note="NPH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT REGION 28..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..456
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 57948 MW; 8D14AFC85EDF0591 CRC64;
MKRWTNLGFV DTIYEDEDYV DHHSSSLSSS SSSLSLSPKQ PINLSSSPSM ELESRVHKWS
LANNSKPDVF VNVGGTRFHL HKDPLSKSGY LKRHLTGVNE LTLSPPLNIT AETFSLVAGF
CYGAHIELTP SNVVSLRIAV EVLLITEADD GGRVRDSLRN LTESYLRRVV FVNVDYIQIV
LRSCLLLLPE SETTAFLIGR CVEALMEIGD GDCVNEFLEE AVKLPAGDFN VVADAVQQRF
PRHDLLYRIV DAYVKEHDGE MTEEEKVQIC NSIDCDKLSP PLLLHAVQNP KMPLRFIVRA
MLQEQLNTRH SIMVAAVAAS CAAPTGVRHR EIATEARDSS VTLGSLLQRD TAARQNCRLR
AAMNSTSSRI ESLEKELDTM KRFLSKESEK QKSDRNIVES RSRSVMDSAR SASFHCVHQP
SNVNKTQRGD RGSVSNLSTT YRRRRASPPQ AQPQKSIGKR LIMGIKNAFS TSSKQVPKKN
AYAVEEIYDG LEDFVWIKDD NDDNISEELH SHYIKNK
