Y3997_ARATH
ID Y3997_ARATH Reviewed; 515 AA.
AC Q9SN21; A0A1I9LRW6;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2018, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Putative BTB/POZ domain-containing protein At3g49970;
GN OrderedLocusNames=At3g49970; ORFNames=F3A4.50;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP DOMAIN BTB.
RX PubMed=15749712; DOI=10.1074/jbc.m413247200;
RA Gingerich D.J., Gagne J.M., Salter D.W., Hellmann H., Estelle M., Ma L.,
RA Vierstra R.D.;
RT "Cullins 3a and 3b assemble with members of the broad
RT complex/tramtrack/bric-a-brac (BTB) protein family to form essential
RT ubiquitin-protein ligases (E3s) in Arabidopsis.";
RL J. Biol. Chem. 280:18810-18821(2005).
CC -!- FUNCTION: May act as a substrate-specific adapter of an E3 ubiquitin-
CC protein ligase complex (CUL3-RBX1-BTB) which mediates the
CC ubiquitination and subsequent proteasomal degradation of target
CC proteins. {ECO:0000250}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC -!- DOMAIN: The BTB/POZ domain mediates the interaction with some component
CC of ubiquitin ligase complexes. {ECO:0000269|PubMed:15749712}.
CC -!- SIMILARITY: Belongs to the NPH3 family. {ECO:0000255|PROSITE-
CC ProRule:PRU00982}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB62105.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL132978; CAB62105.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE78612.2; -; Genomic_DNA.
DR EMBL; CP002686; ANM65324.1; -; Genomic_DNA.
DR PIR; T45850; T45850.
DR RefSeq; NP_001319719.1; NM_001339447.1.
DR RefSeq; NP_001327302.1; NM_001339448.1.
DR AlphaFoldDB; Q9SN21; -.
DR STRING; 3702.AT3G49970.1; -.
DR PaxDb; Q9SN21; -.
DR PRIDE; Q9SN21; -.
DR EnsemblPlants; AT3G49970.1; AT3G49970.1; AT3G49970.
DR EnsemblPlants; AT3G49970.2; AT3G49970.2; AT3G49970.
DR GeneID; 824159; -.
DR Gramene; AT3G49970.1; AT3G49970.1; AT3G49970.
DR Gramene; AT3G49970.2; AT3G49970.2; AT3G49970.
DR KEGG; ath:AT3G49970; -.
DR Araport; AT3G49970; -.
DR TAIR; locus:2083103; AT3G49970.
DR eggNOG; ENOG502QUFV; Eukaryota.
DR HOGENOM; CLU_005994_6_0_1; -.
DR InParanoid; Q9SN21; -.
DR OMA; NFLEYEM; -.
DR OrthoDB; 298243at2759; -.
DR PhylomeDB; Q9SN21; -.
DR UniPathway; UPA00143; -.
DR PRO; PR:Q9SN21; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9SN21; baseline and differential.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR043454; NPH3/RPT2-like.
DR InterPro; IPR027356; NPH3_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR32370; PTHR32370; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF03000; NPH3; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS51649; NPH3; 1.
PE 3: Inferred from homology;
KW Coiled coil; Phosphoprotein; Reference proteome; Ubl conjugation pathway.
FT CHAIN 1..515
FT /note="Putative BTB/POZ domain-containing protein
FT At3g49970"
FT /id="PRO_0000409580"
FT DOMAIN 1..63
FT /note="BTB"
FT DOMAIN 149..409
FT /note="NPH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00982"
FT REGION 395..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 418..452
FT /evidence="ECO:0000255"
FT MOD_RES 350
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q9FMF5"
SQ SEQUENCE 515 AA; 58517 MW; 524CF74B4F6EC621 CRC64;
MLEKLSFLLH KFPLVSKCGF IKKLASESSN DSNIIRIPDF PGGAEGFELV IKFCYDISFE
INTENIAMLL CAAEYLEMTE EHSVENLVET IEVYLNEVIL KSLSKSVKVL QKSQDLLPIA
ERVRLVDRCI DSIAYAICQE SQSNEDIVDW WADDLAVLKI DMFRRVLVAM IARGFKRYSL
GPVLKLYAEK ALRGLDIFGK EAKKMEAEQE HEKRLILETI VSLLPRERNS VSVSFLSILL
RAAIYLETTV ACRLDLEKRM GLQLRQAVID DLLIPYYSFN GDNTMLDVDT VQRILMNYLE
FEVEGNSADF ASDIGELMET YLAEIASDRN INFAKFIGFA ECIPKQSRMY RAIDIFLKTH
PNISEVEKKK VCSLMDCKKL SRDVYAHAAQ NDRFQENLSN SDSPAPATAE KTLSPPELSS
YKNELSKLNR ENQYLKLELL KVKMKFKELE KEKAFEVMSG SDCSSSVSTA SVAKPRLPRK
SFINSVSQKL GKLINPFGLK QGQTKQPKSR RHSIS
