ID   Y4007_STRCO             Reviewed;         430 AA.
AC   Q9ADP8;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Probable transporter SCO4007;
GN   OrderedLocusNames=SCO4007;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   INDUCTION.
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=23831227; DOI=10.1016/j.jmb.2013.06.013;
RA   Hayashi T., Tanaka Y., Sakai N., Okada U., Yao M., Watanabe N., Tamura T.,
RA   Tanaka I.;
RT   "SCO4008, a putative TetR transcriptional repressor from Streptomyces
RT   coelicolor A3(2), regulates transcription of sco4007 by multidrug
RT   recognition.";
RL   J. Mol. Biol. 425:3289-3300(2013).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- INDUCTION: Transcriptionally regulated by SCO4008.
CC       {ECO:0000305|PubMed:23831227}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; AL939118; CAC32347.1; -; Genomic_DNA.
DR   RefSeq; NP_628189.1; NC_003888.3.
DR   RefSeq; WP_011029377.1; NZ_VNID01000032.1.
DR   AlphaFoldDB; Q9ADP8; -.
DR   SMR; Q9ADP8; -.
DR   STRING; 100226.SCO4007; -.
DR   TCDB; 2.A.1.36.4; the major facilitator superfamily (mfs).
DR   GeneID; 1099443; -.
DR   KEGG; sco:SCO4007; -.
DR   PATRIC; fig|100226.15.peg.4070; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_001265_23_0_11; -.
DR   InParanoid; Q9ADP8; -.
DR   OMA; AWAWAGW; -.
DR   PhylomeDB; Q9ADP8; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..430
FT                   /note="Probable transporter SCO4007"
FT                   /id="PRO_0000426731"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        70..90
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        101..121
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..146
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        159..179
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        188..208
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        275..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        315..335
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        362..382
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        383..403
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   430 AA;  43013 MW;  17D82ECE893CDEF8 CRC64;
     MPSSPSSTTP APTSTPAARR EPSGKGPSGA AARLFLPLIA LCTAVTAANI YLAAPLLPLI
     AHDMGSTPSA VAWLASVAQL GYAAGLLFFA PLGDSVNRRR LVAALSLVAT AALLTAAASA
     GTGALAGAVL VASAATVVPQ LLVPLVAERA PADRRARHVA AVIAGLFTGV VAARVLGGLA
     GQAFGWRAVF VGAAVLTAVL GLATAYILPV ERRQRRGPLF AGLVAIPGLV RRSPDLWRAC
     VRQAGMYGAW SALWTSLALL LTEGEGYGMT TAAAGLFGLF GLAASVVAPL AGGLVDRFGA
     AKVVRSAYAL AALSVPLFWL GGQVMAALCA AAVLVHAALV ASHVANQTLA LTTTSAPATA
     NTAYVVAGFA GGALASALAG PAFGHWGWGG VCAVAGAWLV LGWTATAVRP ARSARSARSA
     RSVRSVRSAR